Endpoints as human biomarkers in exposure assessment of triazoles fungicides |
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| Affiliation: | 1. Laboratory of Toxicants and Drugs Analysis – LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, Gabriel Monteiro da Silva street, 700, 37130-000, Alfenas, MG, Brazil;2. Institute of Biological Sciences, Federal University of Alfenas – MG, Gabriel Monteiro da Silva street, 700, 37130-000, Alfenas, MG, Brazil;3. Laboratory of Clinical Analysis – LACEN, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, Gabriel Monteiro da Silva street, 700, 37130-000, Alfenas, MG, Brazil;1. Department of Environmental Science and Policy, University of Milan, via Celoria 26, 20133, Milan, Italy;2. Department of Animal Ecology I and BayCEER, University of Bayreuth, Universitaetsstraße 30, 95447, Bayreuth, Germany;1. College of Life Science, Henan Normal University, Xinxiang, Henan 453007, People’s Republic of China;2. College of Basic Medical, Sanquan College of Xinxiang Medical University, Xinxiang, Henan 453007, People’s Republic of China;1. Department of Pathophysiology, Medical Faculty, University of Belgrade, Belgrade, Serbia;2. Faculty of Electronic Engineering, University of Nis, Nis, Serbia |
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| Abstract: | Potential endpoint biomarkers were evaluated in the assessment of exposure to triazoles, in the southern region of Minas Gerais, Brazil. Volunteers were divided into three groups: occupationally exposed and rural residents (n = 21), non-occupationally exposed and rural residents (n = 35) and non-occupationally exposed and urban residents (n = 30). Of all endpoints evaluated, plasma concentration of androstenedione (p < 0.001) and glycine-conjugated bile acids presented statistical differences in the three studied groups (p < 0.05). However, our findings concerning oxidative stress and testosterone levels, plus that related to unconjugated and taurine conjugated bile acids, suggested that more studies are necessary to evaluate their potential as biomarkers for triazole exposure, as statistical significance was not attained between the groups. Our human population data contributes to the development of triazole exposure risk assessment with respect to these potential effect biomarkers, in potentially vulnerable groups and individuals. |
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| Keywords: | Triazole fungicides Occupational exposure Biomarkers Risk assessment |
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