Exposure to total particulate matter obtained from combustion of diesel vehicles (EURO 3 and EURO 5): Effects on the respiratory systems of emphysematous mice |
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| Affiliation: | 1. Institute of Biomedical Sciences, State University of Ceará, Ceará, Brazil;2. Science and Technology Center, State University of Ceará, Ceará, Brazil;3. Department of Chemistry and Environment, Federal Institute of Ceará, Ceará, Brazil;1. Department of Vascular Surgery, Huadong Hospital, Affiliated with Fudan University, Shanghai 200040, China;2. Department of Vascular Surgery, Zhongshan Hospital, Affiliated with Fudan University, Shanghai 200032, China;1. Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico;2. Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico;3. Facultad de Enfermería, Universidad Autónoma de Zacatecas, Zacatecas, Zacatecas, Mexico;1. Institute of Biomedical Sciences, State University of Ceará, Ceará, Brazil. Av. Dr. Silas Munguba, 1700, 60714-903, Fortaleza-Ceará, Brazil;2. Institute of Biomedical Sciences, State University of Ceará, Ceará, Brazil;3. Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;4. Center of Technological Sciences, State University of Ceará, Ceará, Brazil |
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| Abstract: | Air pollution has association with chronic obstructive pulmonary disease (COPD) and reduced life expectancy. This study investigated the deleterious effects caused by tobacco smoke and diesel exhaust particles (DEP) from vehicles operating under EURO 3 and EURO 5 standards. Experiments were carried out on C57BL/6 mice divided into six groups: control group, group exposed to cigarette smoke (CS), two groups exposed to DEP (AAE3 and AAE5), and two groups exposed to tobacco smoke and vehicle DEP (CSE3 and CSE5). Results showed that, when compared to AA, groups AAE3 and AAE5 showed changes in respiratory mechanics, and that DEP originating from EURO 5 diesel vehicles was less harmful when compared to DEP originating from EURO 3 diesel vehicles. Analyses of groups CSE3 and CSE5 revealed increased inspiratory capacity and decreased tissue elastance, when compared to their respective controls, suggesting an exacerbation of changes in respiratory system mechanics compatible with COPD development. |
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| Keywords: | Pollution Diesel exhaust particles Chronic obstructive pulmonary disease Respiratory system |
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