Angiocentric glioma: A case report and review of the literature |
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| Affiliation: | 1. Department of Neurosurgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China;2. Department of Pathology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China;1. Jiangyan TCM Hospital of Taizhou City, PR China;2. Sichuan Provincial Laboratory of Orthopaedic Engineering, PR China;3. Jiangsu Province Hospital on Integration of Chinese and Western Medicine, PR China;1. Department of Neurosurgery, Kohnan Hospital, Sendai, Miyagi, Japan;2. Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan;1. Department of Medical Oncology, Royal Melbourne Hospital, Grattan St, Parkville, Vic 3050, Australia;2. Department of Medical Oncology, Peter MacCallum Cancer Centre, Grattan St, Parkville, Vic 3000, Australia;3. National Health and Medical Research Council Clinical Trials Centre, University of Sydney, NSW 2006, Australia;4. Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia;5. School of Medicine and Pharmacology, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia;6. Department of Medical Oncology, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW 2065, Australia;7. Department of Medical Oncology, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia;8. Department of Neurology, Austin Health, 145 Studley Road, Heidelberg, Vic 3084, Australia;1. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China;2. International Neuroscience Institute (China-INI), Beijing, China;1. Department of Neurology, Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville TN 37232, USA;3. Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, USA;4. Department of Communication Science and Disorders, University of Pittsburgh School of Health and Rehabilitation Sciences, 5035 Forbes Tower, Pittsburgh, PA 15260, USA;5. Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, 1211 Medical Center Dr, Nashville, TN 37232, USA;1. Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA;2. Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA;3. Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden;4. Department of Clinical Neuroscience and Department of Medicine, Karolinska Institutet, Stockholm, Sweden;5. Department of Neurosurgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark;6. Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA |
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| Abstract: | BackgroundAngiocentric glioma (AG) is a rare, low-grade glioma with slow growth. In 2007, AG was first classified as a solid tumor according to the WHO classification of the central nervous system (WHO class I). The outcome and prognosis of most of the cases are very good, but a few cases with tumor metastasis and disease progression, even death, have been reported. We report a case and systematically analyze previous literature to increase our understanding of the disease and determine the factors that may affect disease progression to make prognostic judgments.Case presentationA young male patient complained of a 3-year history of epilepsy. Anti-epileptic drug treatment was ineffective. An imaging examination revealed a lesion in the left parietal cortex area. Thus, the lesion was completely resected. The pathological diagnosis was angiocentric glioma. During a follow-up of two years, the patient had epilepsy relief controlled by sodium valproate and a disease-free period.ConclusionAG is an epilepsy-related low-grade glioma that heals after complete resection in most reported cases. However, few reported cases have had disease progression and death. This result may be due to the pathological complexity of the diseased tissue. In addition, AG is usually found to have an MYB–QKI rearrangement on genetic analysis. Due to the small number of reported cases and studies, our understanding and knowledge of this disease are still lacking. The potential malignant changes and prognostic factors need to be verified in more than clinical cases and basic research in the future. |
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