单眼弱视多焦视网膜电图的初步研究

目的 应用多焦视网膜电图（multifocal elec-troretinogram,M-ERG)技术，同时记录分析视网膜的线性成分（一阶kernel反应）和非线性成分（二阶kernel反应），从而可以了解视网膜不同层次，不同部位的功能及是否存在异常。方法 共观察了18例单眼性弱视按1987年全国斜弱视学组标准确诊，采用德国Roland公司的多焦视网膜电图，用M系列刺激，检查以黄斑中心凹为中心的5个环61个六边形的一阶kernel反应（firt order kernel,FOK)和二阶kernel反应（second order kernel,SOK)。结果 采用配对t检验进行统计学分析。结果 （1）一阶kernel反应各环的振幅密度值与对侧眼无差异；（2）二阶kernel反应的第一环的振幅密度值均明显低于对侧眼；（3）二阶kernel反应的2-5环的振幅密度值与对侧眼无差异；（4）一阶kernel和二阶ker-nel反应的各环的峰潜时与对侧眼无差异。结论 （1）弱视眼视网膜感光细胞层无异常改变，不存在损害；（2）弱视眼黄斑部可能存在视网膜内层及x型神经细胞的损害；（3）弱视眼神经信息的传递在视网膜层无延长。

Preliminary research on monoocular amblyopia with the multifocal electroretinogram

Objective We respectively record the retinal linear component (first order kernel, FOK) and non-linear component (second order kernel, SOK) applied with the multifocal electroretinogram(M-ERG) so as to understand whether the abnormality of different layers or parts of the retinal function exist in the amblyopic eyes. Methods Eighteen cases of mono-ocular amblyopia were observed. They were examined by far-eyesight and near-eyesight acuity, scotoscoped with the pupil enlarged, and synoptophore testing. They were diagnosed according to the protocol issued by the National Amblyopic Scientific Group in 1987.We used the M-ERG made in Roman Roland Company (RETI-scan 3.15 version) to examine them by FOK and SOK.Results of 5 rings and 61 hexagons circled by the macular fovea. The results were applied comparative t-test to perform statistical analysis.Results (1) There was no difference in FOK reaction of the density value of amplitude of different rings to the other eye of the same patient (P>0.05);(2) The amplitude density value of the first ring in SOK reaction is obviously lower than that of the other eye of the same patient(P<0.01) ;(3) There was no statistical difference in the amplitude density value of the 2~5 rings in SOK reaction to the other eye of the same patient(P>0.05); (4) There was no statistical difference in the latency of different rings in FOK and SOK to the other eye of the same patient (P>0.05); (5) There was no statistical difference between the two groups in F-ERG.Conclusion (1) There exists no abnormal change and no damage in the light-sensitive cell lamina of retina in amblyopic eyes; (2) Maybe in the interior retina lamina, there has x-type ganglion cellular damage in macular part in amblyopic eyes; (3) There is no abnormal change in retinal lamina about the visual stimulation transmission in amblyopic eyes.