| 骨髓间充质干细胞联合基因治疗肝纤维化的研究进展 |
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| 引用本文： | 李明亮,邓美海. 骨髓间充质干细胞联合基因治疗肝纤维化的研究进展[J]. 中华普通外科学文献(电子版), 2011, 5(3): 252-255. DOI: 10.3877/cma.j.issn.1674-0793.2011.03.021 |
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| 作者姓名： | 李明亮 邓美海 |
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| 作者单位： | 中山大学附属第三医院肝胆外,广州,510630 |
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| 摘 要： | 骨髓间充质干细胞治疗肝纤维化的关键在于促进肝细胞再生和抑制肝组织纤维化，但目前单独应用骨髓间充质干细胞治疗肝纤维化的效果不明显，由于骨髓间充质干细胞是外源基因的良好载体，相关研究发现，通过体内、体外将促进肝细胞再生和抑制肝组织纤维化的基因转染骨髓间充质干细胞，可以加强骨髓间充质干细胞治疗肝纤维化的效果，这为肝纤维化的治疗带来新的策略。
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| 关 键 词： | 基因 骨髓间充质干细胞 肝纤维化 细胞因子 |
Progress in research of gene treatment for liver cirrhosis with bone marrow mesenchymal stem cells |
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| LI Ming-liang,DENG Mei-hai. Progress in research of gene treatment for liver cirrhosis with bone marrow mesenchymal stem cells[J]. Chinese Journal of General Surgery(Electronic Version), 2011, 5(3): 252-255. DOI: 10.3877/cma.j.issn.1674-0793.2011.03.021 |
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| Authors: | LI Ming-liang DENG Mei-hai |
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| Affiliation: | LI Ming-liang,DENG Mei-hai. Department of Hepatobiliary Surgery,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China |
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| Abstract: | The key of treatment for liver cirrhosis with bone marrow mesenchymal stem cells lies in the promotion of hepatocellular regeneration and the inhibition of liver tissue fibrosis. However, it＇s not effective to treat liver cirrhosis with bone marrow mesenchymal stem cells alone. For We know that bone marrow mesenchymal stem cells would be fine gene carriers, it can improve the result to treat liver cirrhosis with bone marrow mesenchymal stem cells carrying target gene, which be proved by related research via many experiment methods in-vitro and in-vivo. It brings a new treatment strategy for liver cirrhosis. |
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| Keywords: | Gene Bone marrow mesenchymal stem cells Liver cirrhosis Cytokine |
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