兔上矢状窦中1/3及其回流静脉结扎后颅内压变化

目的探讨兔上矢状窦中1/3结扎与上矢状窦中1/3及其回流静脉结扎后颅内压的变化,为矢状窦旁中1/3脑膜瘤、矢状窦中1/3损伤的治疗提供新思路和实验依据。方法 30只健康家兔,随机分为3组,假手术对照(SO)组10只、上矢状窦中1/3结扎(SSS)组10只、上矢状窦中1/3及其回流静脉结扎(SSS+RV)组10只。建立兔上矢状窦中1/3结扎与上矢状窦中1/3及其回流静脉结扎的动物模型,用光导纤维颅内压监护仪监测结扎后4 h内颅内压的变化。结果家兔上矢状窦中1/3结扎后颅内压逐渐上升,3 h又下降,并维持此水平至4 h,与SO组比较无显著性差异(P>0.05);上矢状窦中1/3及其回流静脉结扎30 min后颅内压开始逐渐上升,约2.5 h后上升明显(P<0.05),与SO组和SSS组相应时间点相比均有显著性差异(P<0.05)。结论单纯上矢状窦中1/3结扎后颅内压变化不大。上矢状窦中1/3及其回流静脉结扎后4 h内颅内压逐渐升高。

Changes of intracranial pressure after occlusion of the middle third of the superior sagittal sinus and its reflux veins in rabbits

Objective To investigate the changes of intracranial pressure after occlusion of the middle third of the superior sagittal sinus and its reflux veins in rabbits to provide the experimental basis for the treatment of the parasagittal meningiomas and the injury on the middle third of the superior sagittal sinus.Methods Thirty healthy rabbits were divided randomly into three groups：sham operation（SO） group（n=10）,the middle third of the superior sagittal sinus occlusion（SSS） group（n=10）,the middle third of the superior sagittal sinus and its reflux veins occlusion（SSS＋RV） group（n=10）.The rabbit models of the middle third of the superior sagittal sinus and its reflux veins occlusion were established.Intracranial pressure（ICP） within 4 h after occlusion was determined by fiberoptic intracranial pressure monitor.Results ICP in SSS group was increased gradually after the operation,began to decrease at 3 h,and maintained this level for 4 h.There was no significant difference between SO and SSS group in ICP（P0.05）.ICP was increased gradually after occlusion of the middle third of the superior sagittal sinus and its reflux veins for 30 min,and increased obviously at 2.5 h（P0.05）.Compared SSS with SO and（SSS＋RV） group,there was significant difference at different time points（P0.05）.Conclusion There is no significant changes of ICP after the occlusion of middle third of the superior sagittal sinus.ICP increases gradually within 4 h after the occlusion of middle third of the superior sagittal sinus and its reflux veins.