阻塞性睡眠呼吸暂停低通气综合征患者下肢静脉血栓发生情况调查分析

依据配对研究原则，对确诊的25例阻塞性睡眠呼吸暂停综合征（OSAHS）患者，按呼吸紊乱指数及最低血氧饱和度分为轻、中、重度，对所有患者进行双下肢静脉超声检查、D-二聚体、血常规检查。随着患者睡眠呼吸暂停低通气病情的加重，发生下肢静脉血栓数比例增高，轻度组中无一例发生下肢静脉血栓，中度组发生2例（2／10），重度组发生3例（3／8）；D-二聚体水平增高，分别为轻度组（498±22）μg／L，中度组（659±43）μg/L，重度组（1528±181）μg/L；血红蛋白轻度组（150±8）g／L，中度组（183±15）g／L，重度组为（261±26）g／L。说明阻塞性睡眠呼吸暂停低通气综合征与静脉血栓栓塞症有一定关系。

Incidence of deep vein thrombosis in patients with obstructive sleep apnea-hypopnea syndrome

Twenty five patients with obstructive sleep apnea hypopnea syndrome (OSAHS) were classified as mild, moderate and severe grade according to apnea hyponea index and lowest oxyhemoglobin saturation.Lower limbs were examined with ultrasonography, blood routine and D-dimer levels were measured in all patients.The results revealed an increased incidence of deep vein thrombosis with the extent of obstructive sleep apnea.There was no deep vein thrombosis in patients with mild-grade OSAHS, while there were 2 in moderate and 3 in severe patients.The blood D-dimer levels were (498 ± 22) pg/L, (659 ±43 ) μg/L, ( 1528 ± 181 ) μg/L in mild, moderate and severe patients, respectively.The hemoglobin levels were (150 ± 8) g/L, ( 183 ± 15) g/L and (261 ± 26) g/L in mild, moderate and severe patients,respectively.There may be some association of obstructive sleep apnea hypopnea syndrome with deep vein thrombosis.