代谢综合征患者血浆氨基末端B型利钠肽前体水平的观察

回顾分析2005-2009年间在我院内分泌科和心内科收治的代谢综合征（MS）患者和非MS患者的临床资料，采用多元线性回归分析Log（NT—proBNP）值与血压、血脂等指标的关系，并采用协方差分析各组间Log（NT—proBNP）值的差异。年龄、体重指数、收缩压、舒张压、胰岛素抵抗指数、甘油三酯、低密度脂蛋白胆固醇、肌酐、左房内径、左室舒张末期后壁厚度、左室射血分数为Log（NT-proBNP）值的独立预测因素；MS组患者Log（NT—proBNP）值明显低于非MS组患者（P〈0．05）；高甘油三酯和体重指数、正常收缩压、舒张压和空腹血糖的MS患者Log（NT—proBNP）值均明显低于非MS患者（P〈0．05）。表明MS患者NT—proBNP水平明品低于非MS患者，这可能与MS患者血脂代谢紊乱和肥胖有关。

Plasma levels of N-terminal pro-B-type natriuretic peptide in patients with metabolic syndrome

A retrospective analysis was made on clinical data of 230 cases of metabolic syndrome (MS) and 239 cases of non-MS admitted to department of cardiology and endocrinology of Huashan Hospital from July 2005 to August 2009.Multiple linear regression analysis was performed to assess the association between levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and potential influencing factors.Covariance analysis was used for group comparison.Multiple linear regression analysis demonstrated that age,body mass index,systolic blood pressure,diastolic blood pressure,insulin resistance index,triglyceride,low density lipoprotein-cholesterol,creatine,left atrial diameter,left ventricular posterior wall dimensions,left ventricular ejection fraction were independent predictors for plasma levels of NT-proBNP in those subjects(P ＜ 0.05).Covariance analysis showed that plasma levels of NT-proBNP in MS group were significantly lower than those in non-MS group ( P ＜ 0.05).Further analysis found that plasma levels of NT-proBNP in MS patients with high triglyceride and body mass index,but normal systolic and diastolic blood pressure,normal fasting plasma glucose were significantly lower than those in non-MS group ( P ＜ 0.05 ).The results indicate that decreased plasma levels of NT-proBNP might be related to lipids disorder and obesity of MS patients.