| 肿瘤相关巨噬细胞促进肿瘤血管生成和转移的研究进展 |
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| 引用本文： | 徐建.肿瘤相关巨噬细胞促进肿瘤血管生成和转移的研究进展[J].复旦学报(医学版),2011,38(1):71-74. |
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| 作者姓名： | 徐建 |
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| 作者单位： | 复旦大学附属中山医院肝癌研究所，上海200032 |
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| 摘 要： | 巨噬细胞起源于血液单核细胞,在不同的刺激因素作用下,巨噬细胞可分化为经典激活的巨噬细胞(M1型)和选择性激活的巨噬细胞(M2型).现在认为,肿瘤相关巨噬细胞(tumor-associated macrophages,TAM)具有M2型巨噬细胞表型.TAM在肿瘤中大量浸润被认为是肿瘤患者预后不良的重要标志.TAM通过多种...
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| 关 键 词： | 肿瘤相关巨噬细胞 肿瘤血管生成 肿瘤转移 |
| 收稿时间： | 2010-4-18 |
Tumor-associated macrophages as promoters of tumor angiogenesis and metastasis |
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| XU Jian.Tumor-associated macrophages as promoters of tumor angiogenesis and metastasis[J].Fudan University Journal of Medical Sciences,2011,38(1):71-74. |
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| Authors: | XU Jian |
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| Institution: | Institute of Liver Cancer, Zhongshan Hospital, Fudan University, Shanghai 200032, China |
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| Abstract: | Macropahges originate from blood monocytes and can differentiate into classically activated macrophages(M1) and alternatively activated macrophages(M2) under different stimulus.As far as we know,tumor-associated macrophages(TAM) was thought to resemble M2-polarized macrophages.The tumor patients whose tumor tissues were infiltrated by lots of TAM were believed to have poor prognosis,and TAM can promote tumor angiogenesis and metastasis by diverse molecular mechanisms.Here,we review the molecular mechanisms ... |
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| Keywords: | tumor-assciated macrophage angiogenesis metastasis |
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