p53和nm23-H1蛋白表达与食管癌浸润转移的关系 |
| |
摘 要: |
|
关 键 词: | 食管癌 侵袭力 肿瘤转移 p53 nm23-H1 基因表达 相关性 |
收稿时间: | 12 June 2002 |
The correlation of p53 and nm23-H1 expression with invasiveness and metastasis in esophageal carcinoma |
| |
Authors: | Liu Ligang Pan Tiecheng Li Jun Zhang Ni Song Dingwei Hu Min |
| |
Institution: | (1) Thoracic and Cardiac Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China |
| |
Abstract: | Objective To study the relationship between expression of p53 and nm23-H1 and differentiation, invasiveness and metastasis in human
esophageal carcinoma, and the correlation between expression of p53 and nm23-H1.
Methods Expression of p53 and nm23-H1 in 50 patients with squamous cell carcinoma of esophagus was detected by using immuno-histochemical
S-P methods.
Results 35 cases (70%) and 32 cases (64%) of esophageal squamous cell carcinoma were positive for nm23-H1 protein and p53 protein,
respectively. The expression of nm23-H1 was related to lymphatic metastasis (P<0.025), but not related to tumor differentiation, invasiveness, tumor location, tumor length, patient's gender and age (P>0.05). The lymphatic metastasis location positive group had a very lower expression of nm23-H1 and the negative rate was
70.8%, but the negative group had a higher expression and the positive rate was 65.4%. The expression of p53 was related to
tumor differentiation and invasiveness (P<0.05), but not related to lymphatic metastasis, tumor location, tumor length, patient's gender and age(P>0.05). Among the three groups, the high differentiation group had the lowest expression of p53 and the positive rate was
29.2%, but the low differentiation group had the highest positive rate (71.4%). As for tumor invasiveness, the group of outer
membrane of esophagus infiltrated had the highest p53 protein positive rate (56%), but in the group, of mucous or submucous
layer infiltrated p53 protien was not detectable. The low expression of nm23-H1 and the high expression of p53 were also correlated.
The expression of nm23-H1 and p53 were both correlated with TNM stage of esophageal carcinoma (P<0.05). The better esophageal carcinomas differentiated, the lower nm23-H1 expressed and higher p53 expressed.
Conclusion Low expression of nm23-H1 and high expression of p53 play an important role in the progression of squamous cell carcinoma
of esophagus. Nm23-H1 might beta gene markef in the prophecy of patients' prognosis and benefit tumor treatment clinically. |
| |
Keywords: | esophageal carcinoma p53 protein nm23-H1 protein |
本文献已被 万方数据 SpringerLink 等数据库收录! |
|