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| 血清C1q抗体对评价狼疮肾炎活动性及疗效的临床意义 | |
| 作者姓名： | Cai XY Yang XY Chen XH Liang LQ Guan MM Qin SG Fu JZ |
| 作者单位： | 1. 510180,广州市第一人民医院风湿科 2. 中山大学附属第一医院风湿科 3. 510180,广州市第一人民医院检验科 4. 510180,广州市第一人民医院肾内科 |
| 摘 要： | 目的 探讨血清C1q抗体对狼疮肾炎活动性及疗效的评价。 方法 用酶联免疫吸附实验 (ELISA)检测 75例活动期狼疮肾炎患者血清中的C1q抗体 ,对 31例狼疮患者作了肾穿刺活检。分析C1q抗体与狼疮肾炎活动性、肾组织病理改变及实验室参数的相关性。并对全部病例进行随访 ,分析血清C1q抗体及治疗后的变化对狼疮肾炎疗效的影响。 结果 5 5例 (73 3% )狼疮肾炎患者血清C1q抗体阳性 ,抗体水平 92U/ml± 4 1U/ml;血清C1q抗体水平与狼疮肾炎临床活动指数、尿蛋白含量以及双链DNA(ds DNA)抗体滴度呈正相关 ,与补体C3、C4水平呈负相关 ;血清C1q抗体水平与肾脏病理改变的活动指数呈正相关 ;COX回归多因素分析显示 ,血清C1q抗体及治疗后的C1q抗体水平与狼疮肾炎尿蛋白转阴存在相关性 ,后者更有意义。结论 C1q抗体不仅与狼疮肾炎活动性相关 ,而且在一定程度上反映肾脏病变程度 ,监测治疗后抗体水平的变化可以为评价疗效及指导临床治疗提供重要依据。 |
| 关 键 词： | 狼疮肾炎 比例危险度模型 C1q抗体 |
| 修稿时间： | 2004年2月12日 |
Significance of serum anti-Clq Ab in evaluation of lupus nephritis activity and its curative effects of pharmacotherapy on lupus nephritis |
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| Cai XY,Yang XY,Chen XH,Liang LQ,Guan MM,Qin SG,Fu JZ.Significance of serum anti-Clq Ab in evaluation of lupus nephritis activity and its curative effects of pharmacotherapy on lupus nephritis[J].National Medical Journal of China,2004,84(17):1436-1439. | |
| Authors: | Cai Xiao-Yan Yang Xiu-Yan Chen Xiao-Hui Liang Liu-Qin Guan Ming-Mei Qin Shu-Guang Fu Jun-Zhou |
| Institution: | Department of Rheumatology, the First Municipal People's Hospital, Guangzhou 510180, China. |
| Abstract: | OBJECTIVE: To investigate the significance of serum anti-C1q Ab of evaluation of lupus nephritis activity and its curative effects of cyclophophamide therapy on lupus nephritis (LN). METHODS: The level of serum anti-C1q antibody of 75 patients with LN was examined by enzyme-linked immunosorbent assay (ELISA) of the 75 patients the incipient cases had never received corticosteroid and immunosuppressant and the recurrent cases had stopped the immunosuppressant treatment for more than 3 months and were treated, if so, with prednisone with the dosage |
| Keywords: | Lupus nephritis Proportional hazards models Anti-C1q Ab |
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