Effect of ipratropium bromide on respiratory mechanics in infants with acute bronchiolitis |
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Authors: | J. SEIDENBERG I. B. MASTERS I. HUDSON A. OLINSKY P. D. PHELAN |
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Affiliation: | Professorial Department of Thoracic Medicine, Royal Children's Hospital and Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia |
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Abstract: | The effect of nebulized ipratropium bromide in 14 infants (mean age:20 weeks, range:4–41) with acute respiratory syncytial virus bronchiolitis was examined. A modified rapid chest compression technique was used to obtain partial expiratory flow-volume curves and maximum flow at functional residual capacity. Passive respiratory mechanics were assessed by brief occlusion at end inspiration. Thoracic gas volume was measured in a body plethysmograph. No significant difference was found in forced and passive respiratory mechanics pre- and post-ipratropium bromide. No subgroups could be identified. These results do not support the use of ipratropium bromide in acute viral bronchiolitis. |
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Keywords: | bronchiolitis ipratropium bromide partial expiratory flow-volume curves passive respiratory mechanics |
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