Intercellular junctional specializations in human basal cell carcinoma |
| |
Authors: | Zoltan Posalaky Dennis McGinley Bruce Cutler H. Irving Katz |
| |
Affiliation: | (1) Departments of Pathology and Dermatology, St. Paul Ramsey Medical Center, 55101 St. Paul, Mn., USA;(2) University of Minnesota, 55455 Minneapolis, Mn., USA |
| |
Abstract: | Summary Intercellular junctions of various types were found on the membrane fracture faces of human nodular basal cell carcinoma (BCC) cells. The junctional types represented include desmosomes, tight junctions, and gap junctions. A semiquantitative comparison of undifferentiated and differentiated nodular BCC showed that gap and tight junctions were observed on all exposed membrane fracture interfaces of the differentiated tumors, while only fifty six per cent of the membrane interfaces of the undifferentiated tumor exhibited similar junctional specializations. These membrane specializations may be a partial reflection of differentiation among the different types of BCC and their contribution to the less invasive character of nodular BCC cannot be ruled out.Preliminary results from this study were presented at the X Triennial World Congress of Pathology Sept. 25–29, 1978, Rio de Janeiro, Brazil |
| |
Keywords: | Freeze fracture Desmosomes Gap junctions Tight junctions |
本文献已被 SpringerLink 等数据库收录! |
|