复脑灵口服液对小鼠记忆功能的改善作用及其机制

目的观察复脑灵口服液对小鼠获得性记忆、肠系膜循环障碍及超氧化物歧化酶 (SOD)的作用。方法昆明种小白鼠40只 ,随机分为复脑灵组、脑复康组、模型组、对照组 ,给药 10天后 ,腹腔注射东莨菪碱 1mg/kg造成小鼠记忆障碍模型 ,跳台实验测定其记忆功能 ;光镜下观察去甲肾上腺素缩血管后 ,复脑灵、百年乐的对抗作用 ,并与对照组进行比较 ;随机分组后给复脑灵口服液 75、3 7 5、18 75 g生药 /kg 3个剂量、脑复康后测小鼠血清SOD活性。 3种实验均设空白对照。 结果复脑灵口服液可改善小鼠记忆障碍及小鼠肠系膜微循环 ,提高血清SOD活性 ,与对照组比较有显著性差异 (P <0 0 5或P <0 0 1)。结论复脑灵口服液对小鼠获得性记忆障碍及肠系膜循环障碍有改善作用 ,可提高小鼠血清SOD活性。

Improvement of memory function of mice by Funaoling Oral Liquid

ObjectiveTo explore the effect of Funaoling Oral Liquid on improving memory function of mice.Methods30 mice were injected with scopolamine 1mg/kg to make model of memory obstacle after treated by Funaoling Oral Liquid,piracetam or saline for 10 days.The escape test was used to measure the memory function.The blood circulation obstacle of the mice in mesentery was made by norepinephrine,and then, Funaoling Oral Liquid, Happy-hundred-year Oral Liquid and saline were given to observe the recovery time. The serum superoxide dismutase(SOD) activity in mice was measured after using different dosage of Funaoling Oral Liquid(75g/kg,37.5 g/kg and 18.75g/kg),piracetam or saline for 10 days.ResultsFunaoling Oral Liquid improved the memory function and blood circulation of mesentery significantly compared with that of the model(P<0.05 or P<0.01). The serum SOD activity in mice which was treated by Funaoling Oral Liquid 18.75g/kg were higher than that of model(P<0.05).ConclusionsThe Funaoling Oral Liquid can improve the memory and blood circulation of mice after injured,as well as to enhance the activity of SOD. [