非小细胞肺癌淋巴管生成因子表达与淋巴结转移关系的研究

背景与目的 血管内皮生长因子C（VEGF-C）可以诱导淋巴管上皮细胞增殖和淋巴窦的新生。本研究的目的是探讨VEGF-C的表达与非小细胞肺癌淋巴结转移的关系。方法 应用免疫组织化学S-P法对60例非小细胞肺癌组织中VEGF-C蛋白的表达进行测定，并结合肺癌的淋巴结转移特征进行分析。结果 肺癌组织中VEGF-C蛋白阳性表达率为65．00％（39／60）。有淋巴结转移组VEGF-C蛋白阳性表达率83．33％（20／24）明显高于无淋巴结转移组52．78％（19／36）（P〈0．05）。结论 肺癌组织中存在VEGF-C的高表达，可能与肺癌的淋巴结转移有关。VEGF-C蛋白表达可能作为推断肺癌淋巴结转移的参考指标。

Relationship between expression of VEGF-C and lymph node metastasis in human non-small cell lung cancer

Background and objective It has been showed that VEGF-C can induce the proliferation of lymphocytes. The aim of this study is to explore the expression of VEGF-C in human non-small cell lung can-cer (NSCLC) and its relationship with lymph node metastasis. Methods The expression of VEGF-C was examined in 60 human NSCLC tissues by immunohistochemical technique. Results The positive rate of VEGF-C expression was 65.00% (39/60) in NSCLC tissues. The expression of VEGF-C was significantly higher in cases with lymph node metastasis (83.33%, 20/24) than in those without lymph node metastasis (52.78%, 19/36) (P<0.05). Conclusion There is an overexpression of VEGF-C protein in human NSCLC tissues, which may correlate with lymph node metastasis. The expression of VEGF-C protein might be used as a useful mar- ker of lymph node metastasis in NSCLC.