Elevated spontaneous mutation rate in SV40-transformed werner syndrome fibroblast cell lines |
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| Authors: | Ken-ichiro Fukuchi Kiyoji Tanaka Jun Nakura Yuichi Kumahara Tsuyoshi Uchida Yoshio Okada |
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| Affiliation: | (1) Department of Medicine and Geriatrics, Osaka University Medical School, Fukushima-ku, 553 Osaka, Japan;(2) Institute for Molecular and Cellular Biology, Osaka University, Yamada-oka, Suita, 565 Osaka, Japan |
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| Abstract: | Spontaneous mutation rates of the cells from patients with Werner syndrome were examined, and we found that the spontaneous mutation rates at the hypoxanthine-guanine phosphoribosyltransferase locus in SV40-transformed Werner syndrome cell lines were markedly elevated, compared to those in SV40-transformed normal control cell lines. Our results suggest that Werner syndrome is a mutation mutant. |
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