鳞状细胞癌抗原与原发性肝癌相关性研究进展

<正>原发性肝癌(hepatocellular carcinoma,HCC)是世界上最常见的恶性肿瘤之一[1]。目前HCC的临床诊断主要依赖于影像学证据、血清学指标及肝组织的病理学和细胞学检查。其中影像学方法无法准确判断占位的良、恶性,而肝脏穿刺病理学检查是有创检查,一般医院尚难开展,甲胎蛋白(α-fetoprotein,AFP)是目前常用的HCC标记物,但其敏感性及特异性均不高。近年来,鳞状细胞癌抗原(squa-

Associated progress between squamous cell carcinoma antigen and hepatocellular carcinoma

Hepatocellular carcinoma(HCC)is the 6_th most common tumour in the world.Because its rapid progress and high transfer rate,early diagnosis and prompt treatment are important to HCC patients" prognosis. Squamous cell carcinoma antigen(SCCA) was a tumor-associated protein.The SCCA serum levels and the express of SCCA in the tumoral tissues of HCC patients is obviously higher. SCCA expression in HCC tissues can serve as an early diagnosis mark of small HCC and liver tissue micro-metastases. Serum SCCA testing for early diagnosis of HCC is better than AFP. The combined use of SCCA and AFP can improve the sensitivity of the diagnosis of HCC. So,SCCA may become a new tumor maker for HCC.