Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated acute renal failure |
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Authors: | R A Stone C C Tisher H K Hawkins R R Robinson |
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Institution: | Durham, North Carolina USA |
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Abstract: | The etiology of renal failure in progressive systemic sclerosis remains unexplained. In this patient with progressive systemic sclerosis rapidly progressive azotemia developed resulting in death. Kidney tissue obtained by percutaneous renal biopsy and later at autopsy revealed striking hyperplasia of the juxtaglomerular apparatus. The plasma renin activity measured by bioassay was extremely high. The clinical and morphologic findings in this patient suggest a possible pathophysiologic role for the renin-angiotensin system in the acute renal decompensation that occasionally occurs in progressive systemic sclerosis. |
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Keywords: | Requests for reprints should be addressed to Dr C Craig Tisher Box 3014 Duke University Medical Center Durham North Carolina 27710 |
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