P27和P21在喉鳞状细胞癌中的表达

目的探讨细胞周期调节因子P27和P21在喉鳞状细胞癌中的表达及临床意义。方法采用免疫组织化学（SP）法检测P27和P21在72例喉癌和21例正常喉粘膜中的表达。结果喉癌中P27和P21阳性表达率分别为30.6%、26.4%,与正常喉粘膜比较差异有统计学意义（P〈0.05）;喉癌的不同分化程度及是否有淋巴结转移,P27和P21在喉癌中的表达水平差异有统计学意义（P〈0.05）,但与发病部位无关（P〉0.05）。结论 P27和P21与喉癌的发生密切相关,检测P27和P21对喉癌的早期诊断、治疗及预后有重要意义。

Significance of expression of P27 and P21 in laryngeal squamous cell carcinoma Patients

Objective To investigate the clinical significance of expression of P27 and P21 in patients with laryngeal squamous cell carcinoma.Methods Immunohistochemistry method（SP）was used to detect the expressions of P27 and P21 in 72 laryngeal carcinoma cases and 21 normal mucosa controls.Results The positive rates of P27and P21 in laryngeal carcinoma were 30.6%、26.4%.There were significant difference compared with normal mucosa of laryngea（l P0.05）.Expression of P27 and P21 was significantly correlated with the degree of differentiation and lymph node metastasis of laryngeal carcinoma（P0.05）,but they were irrelatively with location（P0.05）.Conclusions The concentrations of P27 and P21 were closely correlated with occurrence of laryngeal carcinoma.It is of important significance in detecting the expression of P27 and P21 for early diagnosis,treatment and prognosis of laryngeal carcinoma.