乳腺导管原位癌超声图像特征及其与病理因素的关系

目的:观察乳腺导管原位癌(DCIS)超声图像特征,探讨其与Her-2蛋白表达等病理因素的关系.方法:回顾性分析66例乳腺导管原位癌的临床资料,分析患者超声图像的特征及肿块大小与钙化、浸润、Her-2表达的关系.结果:66例患者中,肿瘤＞1cm者42例,超声表现为形态不规则,边界不清的低回声区；肿瘤≤1 cm者24例,其中超声表现为导管扩张者7例,小结节9例,腺体增厚8例.超声检查肿块＞1cm的DCIS中,其钙化率低于≤1 cm者,但浸润率和Her-2阳性表达率均明显高于肿块≤1 cm者(均P＜0.05).超声检查诊断DCIS与病理结果的符合率为51％.结论:DCIS的超声表现具有特征性,肿块≤1 cm者常伴钙化,肿块＞1cm者提示预后不良.

Ultrasound image features of ductal carcinoma in situ and their relations with pathological profiles

Objective: To analyze the ultrasound image features of ductal carcinoma in situ (DCIS), and their relations with the pathological profiles. Methods: The clinical data of 66 DCIS patients were reviewed, and then the ultrasound image features of the patients and the relationships between the lesion size and calcification, infiltration and Her-2 expression were analyzed. Results: Of the 66 patients, the lumps in 42 cases were larger than 1 cm, which presented as hypoechoic areas with irregular shape and unclear border in the ultrasound image; the lumps in 24 cases were less than or equal to 1 cm, which presented as duct dilation (7 cases), small nodule (9 cases), or gland thickening (8 cases). In DCIS larger than 1 cm, the calcification rate on ultrnsound examination was lower but infiltration and Her-2 positive expression rate were higher than those in DCIS less than or equal to 1 cm (all P<0.05). The coincidence rate of ultrasound examination for diagnosis of DCIS with the final pathological results was 51%. Conclusion: DCIS has its own characteristics in ultrasound images, and the lump less than or equal to 1 cm is often accompanied with calcification, while the lump larger than 1 cm may predict a poor prognosis.