| Bcl-XL反义寡核苷酸转染对食管癌细胞系和裸鼠人食管癌移植瘤增殖、生长抑制作用的实验研究(英文) |
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| 作者单位： | Lei Zhang(Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China);Hongtao Wen(Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China);Lan Zhang,Dongling Gao,Shenglei Li,Fengyu Cao,Kuisheng Chen,Yunhan Zhang(Henan Key Laboratory of Tumor Pathology; Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China) |
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| 基金项目： | Supported by a grant from the Henan Innovation Project for University Prominent Research Talents (No. 2007KYCX005) |
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| 摘 要： |
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| 关 键 词： | 反义寡核苷酸 食管癌 BCI 细胞系 转染 生长 移植 裸鼠 |
| 收稿时间： | 2010-06-02 |
Inhibitory effects of transfected Bcl-XL antisense oligodeoxynucleotide to proliferation and growth in esophageal carcinoma cell line and human esophageal carcinoma xenograft of nude mice |
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| Lei Zhang,Hongtao Wen,Lan Zhang,Dongling Gao,Shenglei Li,Fengyu Cao,Kuisheng Chen,Yunhan Zhang. Inhibitory effects of transfected Bcl-XL antisense oligodeoxynucleotide to proliferation and growth in esophageal carcinoma cell line and human esophageal carcinoma xenograft of nude mice[J]. The Chinese-German Journal of Clinical Oncology, 2010, 9(3): 169-174. DOI: 10.1007/s10330-010-0006-x |
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| Authors: | Lei Zhang Hongtao Wen Lan Zhang Dongling Gao Shenglei Li Fengyu Cao Kuisheng Chen Yunhan Zhang |
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| Affiliation: | [1]Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China [2]Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China [3]Henan Key Laboratory of Tumor Pathology; Department of Pathology.The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China |
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| Abstract: | Objective:The aim of our study was to investigate the biological effects of Bcl-XL antisense oligodeoxynucleotide(ASODN) transfected into cultured esophageal carcinoma cells and human esophageal carcinoma xenograft in nude mice.Methods:Cationic liposome-mediated ASODN was used to transfect esophageal carcinoma cells.RT-PCR, Western blot, MTT assay, flow cytometry, and in situ apoptosis cells detection(TUNEL detection) were used to systematically study the biological effects of transfected cells both in vitr... |
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| Keywords: | esophageal neoplasms Bcl-XL nude mice liposome oligonudeotide antisense |
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