Randomized double-blind comparison of isosorbide dinitrate and nifedipine in variant angina pectoris |
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| Affiliation: | 1. State Key Laboratory of Modern Chinese Medicine, Tianjin University of traditional Chinese Medicine, Tianjin, PR China;2. State Key Laboratory of Modern Chinese Medicine, Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin University of Traditional Medicine, Nankai District, Tianjin, PR China;3. Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, NanKai District, Tianjin, PR China;1. Department of Clinical Pharmacology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China;2. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China;3. Department of Cardiology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China;4. Department of Cardiology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China;1. Faculty of Mechanical Engineering and Automation, Zhejiang Sci-Tech University, Hangzhou, 310018, China;2. School of Information Science and Technology, Zhejiang Sci-Tech University, Hangzhou, 310018, China;3. Zhejiang Main Laboratory of Planting Equipment Technology, Hangzhou, 310018, China;1. Center for Post-doctoral Research, China Academy of Chinese Medical Sciences, 100700, China;2. National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, 100700, China;3. Tasly Academy, Tasly Holding Group Co., Ltd., Tianjin 300410, China;4. Skate Key Laboratory of Core Technology in Innovation Chinese Medicine, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China;5. Heilongjiang University of Chinese Medicine, Harbin 150040, China;6. Tasly Pharmaceuticals Inc, Rockvill, MD 20850, USA;1. Department of Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d''Alcontres, 31 98166 S.Agata, Messina, Italy;2. Research Group on Community Nutrition and Oxidative Stress (NUCOX), University of Balearic Islands, E-07122 Palma de Mallorca, Balearic Islands, Spain;3. CIBEROBN (Physiopathology of Obesity and Nutrition), E-07122 Palma de Mallorca, Balearic Islands, Spain;4. National Institute of Health Dr. Ricardo Jorge, I.P., Department of Food and Nutrition, Av. Padre Cruz, 1649-016 Lisbon, Portugal;5. Centro de Estudos de Ciência Animal (CECA), ICETA – Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto, Universidade do Porto – Praça Gomes Teixeira, Apartado 55142, 4051-401 Oporto, Portugal;6. Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Hațieganu”, Ghe. Marinescu 23, 400337 Cluj-Napoca, Romania;7. ICHAT and Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania;8. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing;2. Graduate Institute of Health-Industry Technology, Research Center for Food and Cosmetic Safety, and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan City;3. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung;4. Natural Products Laboratory, Institute of Biology, Leiden University, Leiden;5. Department of Pharmacology, Yale University School of Medicine, New Haven, CT |
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| Abstract: | The antianginal and anti-ischemic effect of isosorbide dinitrate (ISDN), 120 mg once daily, and nifedipine, 20 mg twice daily, both in slow-release formulations, were compared in 17 patients with variant angina pectoris in a randomized, double-blind trial. The design included a placebo run-in period and two 6-week crossover periods of active treatment. Mean frequency of angina decreased significantly from 43 attacks per week during the placebo period to 4 per week with ISDN and 8 with nifedipine (p < 0.001). Sublingual nitroglycerin consumption decreased significantly from 37 tablets per week with placebo to 3 tablets per week with ISDN and 7 with nifedipine (p < 0.001). Both drugs reduced the silent and symptomatic ST-segment deviations on ambulatory electrocardiographic recording and increased maximal exercise tolerance. Episodes of coronary spasm could be provoked, by hyperventilation, in all patients during the placebo phase but in no patient during therapy with either active drug.Thus, both ISDN and nifedipine, in their slow-release formulations, are effective in the treatment of variant angina pectoris. |
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