Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy |
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| Authors: | Masahiro Ohira Yasuhiro Watanabe Takashi Yamaguchi Hiroki Onda Shuhei Yamaoka Kazuki Abe Shoko Nakamura Sho Tanaka Naoyuki Kawagoe Taiki Nabekura Takashi Oshiro Daiji Nagayama Ichiro Tatsuno Atsuhito Saiki |
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| Affiliation: | aDivision of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan;bCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan;cDepartment of Surgery, Toho University Sakura Medical Center, Chiba, Japan;dNagayama Clinic, Tochigi, Japan;eChiba Prefectural University of Health Sciences, Chiba, Japan |
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| Abstract: | IntroductionLaparoscopic sleeve gastrectomy (LSG) significantly increases high-density lipoprotein cholesterol (HDL-C) and lipoprotein lipase (LPL) in pre-heparin serum (pre-heparin LPL levels). LPL is a regulator of serum triglyceride (TG) and HDL-C production; this may be the mechanism for HDL-C increase after LSG. This study aimed to elucidate the mechanism of increase in HDL-C levels by examining the relationship between changes in serum HDL-C levels and LPL after LSG.MethodsWe retrospectively reviewed 104 obese patients, who underwent LSG and were followed up for 12 months. We analyzed the relationship between changes in serum HDL-C levels and various clinical parameters after LSG.ResultsA significant decrease was observed in the patients'' BMI and serum TG levels after LSG. Conversely, HDL-C levels and pre-heparin LPL levels were significantly increased after LSG. Simple linear regression showed that changes in HDL-C levels were significantly correlated with total weight loss percentage, change in TG levels, abdominal fat areas, and pre-heparin LPL levels. Additionally, the multiple regression model revealed that a decrease in TG levels and an increase in pre-heparin LPL levels were correlated with increased HDL-C levels after LSG.Discussion/ConclusionThese results show that a decrease in TG levels and an increase in LPL are mechanisms for increased HDL-C levels after LSG. |
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| Keywords: | Obesity Laparoscopic sleeve gastrectomy High-density lipoprotein cholesterol Triglyceride Lipoprotein lipase |
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