联合检测CA125和雌孕激素受体在子宫内膜癌中的作用

目的探讨血清CA125和雌激素受体(ER)、孕激素受体(PR)在子宫内膜癌中与手术分期、病理分级的关系。方法收集我院经手术治疗子宫内膜癌的患者43例,术前放射免疫法检测血清CA125,术后病理免疫组化检测ER、PR。结果单一检测CA125,CA125阳性率与手术分期有关(P<0.05),与病理分级无关(P>0.05);单一检测ER、PR,ER的阴性率与手术分期有关(P<0.05),与病理分级无关(P>0.05),PR阴性率与手术分期和病理分级都有关(P<0.05);联合三项在手术分期和病理分级均明显高于三项单独检测值(P<0.05),三项均阳性(CA125值阳性、ER和PR阴性)时提示患者病理分级为中低分化,手术分期中浸润深肌层或附件转移或淋巴结转移,预后差。结论联合检测三项在判断子宫内膜癌的预后优于单一检测。

Effection of Combinative Detection of Serum CA125 and Estrogen receptor and Pregnant receptor on Endometrial Cancinoma

ObjectiveTo study serum CA_(125) and estrogen receptor and pregnant receptor relationships to surgical stage and histological grade on endometrial cancer.Methods43 cases of endometrial carcinoma according to the postoperative pathological examination were detected serum CA_(125) before operation and ER and PR by immunohistochemical staining after operation.ResultsIn single detecting CA_(125), the difference of CA_(125) positive rate in surgical stage was significant(P<0.05), but the expression of CA_(125) positive rate in histological grade had no statistical difference(P>0.05); In single detecting ER or PR, ER negative rate were related to surgical stage(P<0.05) and PR negative rate were related to surgical stage and histological grade(P<0.05); The values in combinative detection index were higher than those in single detection index on surgical stage and histological grade(P<0.05),three positive terms can predict the patients of grade or grade on histological grade and deep muscular wall metastasis or adnexa metastasis or lymph node metastasis on surgical stage and poor prognosis. ConclusionIN estimation prognosis of endometrial carcinoma, the method of combinative detection index is better than the way of single detection index.