脑小血管病变和抑郁的关系

脑小血管病变是指一组累及脑部小动脉、细动脉和静脉以及毛细血管病变的总称，影像学特点主要包括脑白质病变、腔隙性脑梗死和微出血。脑小血管病变与抑郁的发病及预后相关，其主要的作用机制为小血管病变破坏了皮质-纹状体-苍白球-丘脑皮质环路。本文针对脑小血管病变与抑郁的关系这一热点问题，分别从脑白质病变、腔隙性脑梗死及微出血与抑郁的关系方面对其进行阐述。

Relationship between Cerebral Small Vessel Disease and Depression

The term cerebral small vessel disease refers to a group of pathological processes with various aetiologies that affect the small arteries, arterioles, venules, and capillaries of the brain. The cerebral small vessel disease in imaging are mainly include white matter lesions, lacunar infarcts and microbleeds. It＇s related to the incidence and prognosis of depression, the main mechanism is that small vascular lesions destroy the cortico-striato-pallido-thalamo-cortical（CSPTC） systems This review aims to summarize the relations between the cerebral small vessel disease and depression respectively from the white matter lesions, brain of lacunar infarcts and microbleeds.