苯磺酸氨氯地平片联合坎地沙坦酯治疗老年性高血压的临床观察

目的：观察苯磺酸氨氯地平片联合坎地沙坦酯治疗老年性高血压的临床疗效。方法：选择2010年住院老年性高血压患者48例,晨起口服苯磺酸氨氯地平片5mg,1次/d,坎地沙坦酯4mg,1次/d,疗程为10～14d,观察患者服用苯磺酸氨氯地平及坎地沙坦酯片后血压的变化和不良反应。结果：治疗10～14d后,血压由（163±17）/（90±24）mmHg下降至（133±14）/（70±10）mmHg,治疗前后比较,差异有统计学意义（P〈0.05）。显效30例（62.50%）,有效15例（31.25%）,无效3例（6.25%）,总有效率为93.75%。结论：苯磺酸氨氯地平联合坎地沙坦酯治疗老年性高血压安全有效。

To assess the treatment outcome on lower blood pressure in the old by using candesartan cilexetil and amlodipine besylate

Objective： To assess the clinical effects of candesartan cilexetil combined with amlodipine besylate on senile hypertension. Methods： Forty-eight inpatients with senile hypertension during 2010 were selected to receive candesartan cilexetil, 4 mg, qd, combined with amlodipine besylate, 5 mg, qd for 10-14 days, and the changes on blood pressure and untoward effect were observed. Results： The systole blood pressure decreased from （163±17） mmHg to （133±14） mmHg （P〈0.05）, and dystole biood pressure decreased from （90±24） mmHg to （70±10） mmHg （P〈0.05） after treatment of 10-14 days. Thirty cases （62.50%） were excellent effect, and 15 cases （31.25%） were effective, 3 cases （6.25%） were ineffective and total effective rate was 93.75%. Conclusion： The treatment of candesartan cilexetil combined with amlodipine besylate is effective and safe for the patients with senile hypertension.