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Severity of demyelination in vivo correlates with serum myelination inhibition activity in guinea pigs having a new form of experimental allergic encephalomyelitis |
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| Authors: | Dennis N. Bourdette Bernard F. Driscoll Fredrick J. Seil Marian W. Kies Ellsworth C. Alvord |
| Affiliation: | 1. Neurology Research, Veterans Administration Medical Center and Department of Neurology, Oregon Health Sciences University, 97201, Portland, OR 2. Section of Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, 20205, Bethesda, MD 3. Laboratory of Neuropathology, Department of Pathology, University of Washington Medical School, 98195, Seattle, WA |
| Abstract: | Guinea pigs received a suboptimal transfer of lymphocytes sensitized to myelin basic protein (BP) and were then immunized with guinea pig BP, BP plus chicken brain or chicken myelin, or chicken brain alone. Sera from these animals were tested for the presence of myelinotoxic antibodies, as detected by the myelination inhibition assay. Myelination inhibition activity correlated with the histologic severity of demyelination. |
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