The effect of milk fermented by yogurt cultures plus <Emphasis Type="Italic">Lactobacillus casei</Emphasis> DN-114001 on the immune response of subjects under academic examination stress |
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Authors: | Email author" target="_blank">Ascensión?MarcosEmail author Julia?W?rnberg Esther?Nova Sonia?Gómez Alberto?Alvarez Rocío?Alvarez José?A?Mateos José?M?Cobo |
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Institution: | (1) Grupo Inmunonutrición, Depo. de Metabolismo y Nutrición, Instituto del Frío, CSIC, C/Jose Antonio Novais 10, 28040 Madrid, Spain;(2) Unidad de Citometría Centro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain;(3) Coordinación Científica, Danone S. A., Barcelona, Spain |
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Abstract: | Summary
Background
A suppressed immune response has been documented in students under examination stress.
Aims
The current study aimed to evaluate the effect of milk fermented with yogurt cultures plus Lactobacillus casei DN-114001 (Actimel®) on the immune system of subjects under academic examination stress.
Methods
University students were allocated to one of two groups, receiving during 6 weeks (3 weeks prior to, as well as the 3-week duration of the examination period) either: a) a glass of semi-skimmed milk each day (control group, n=63) or b) two 100mL portions per day of fermented milk (treatment group, n=73). Anxiety and immunological measurements were monitored at baseline (Phase 0) and study end (Phase 1).
Results
The results were expressed as the differences between the data obtained from Phase 0 and Phase 1. This was calculated by subtracting Phase 1 results from the Phase 0 and it is denominated Treatment effect. Mean (± SE) anxiety increased significantly (P<0.05) over the 6-week study in all students, from 40.74±2.50 to 61.19±2.64 (in percentiles). There was no significant treatment effect since this increase was similar in the control and the treatment groups (21.65±5.09 vs 19.14±3.67, respectively). However, there was a significant treatment effect (P<0.05) on the mean change in absolute number of lymphocytes during the 6-week study, which decreased in the control group (–0.04±0.12 cells x 103/mm3) and increased in the treatment group (0.37±0.11 cells x 103/mm3). There was also a significant treatment effect (P<0.05) on the change in absolute numbers of CD56 cells during the 6-week study. Mean absolute CD56 cells significantly decreased (P<0.05) in the control group (–51.97±21.33 cells/mm3),while remaining similar in the treatment group (17.29±17.27 cells/mm3). During the study, mean serum cortisol increased 4.30±0.98 µg/dL in the control group, and 1.75±1.05 µg/dL in the treatment group and no significant differences were found between both values (P=0.062).
Conclusions
Milk fermented with yogurt cultures plus Lactobacillus casei DN-114001 was able to modulate the number of lymphocytes and CD56 cells in subjects under academic examination stress. |
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Keywords: | fermented milk Lactobacillus casei DN114001 examination stress immunomodulation cortisol |
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