A Case of Osteoclast-like Giant Cell Tumor of the Pancreas Associated with Borderline Mucinous Cystic Neoplasm |
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Authors: | George Burkadze Gulisa Turashvili |
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Institution: | (1) Department of Pathology, N. Kipshidze Central University Clinic, Vazha-Pshavela Avenue, 0160 Tbilisi, Georgia;(2) BC Cancer Research Centre, 675 W 10th Avenue, Vancouver, BC, V5Z 1L3, Canada |
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Abstract: | A 34-year-old, previously healthy female presented with severe acute upper quadrant abdominal pain and an 11-cm cystic mass
in the tail of the pancreas. The patient underwent distal pancreatectomy with total gross excision of the mass. Grossly, the
mass consisted of a multiloculated cystic lesion measuring 11.7 cm in its greatest dimension. An irregular solid lobulation
at the lateral aspect of the cyst was visible, measuring 3 cm in the largest dimension. Histologically, there were two distinct
components: a mucinous, neoplastic epithelial cyst with few foci of moderate atypia, and nodular spindle cell areas containing
multinucleated tumor giant cells. Immunohistochemically, the multinucleated giant cells were positive for vimentin, CD68 and
CD45, and negative for cytokeratin and epithelial membrane antigen (EMA). The spindle cells of hypercellular stroma were stained
for vimentin, but not for EMA or carcinoembryonic antigen (CEA). Neuron-specific enolase (NSE), S100 and Ki-67 showed no reactivity.
The histological diagnosis “osteoclast-like giant cell tumor of the pancreas associated with borderline mucinous cystic neoplasm”
was made. The patient recovered and is free of disease 4 years after the diagnosis. |
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Keywords: | Osteoclast-like giant cell tumor Mucinous cystic neoplasm Immunohistochemistry Pancreas |
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