31P magnetic resonance spectroscopy of the medial temporal lobe of schizophrenic patients with neuroleptic-resistant marked positive symptoms |
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Authors: | Hiroshi Fukuzako Kouzou Takeuchi Kenichi Ueyama Tsuyoshi Fukuzako Yoshiro Hokazono Kyuroku Hirakawa Kouichiro Yamada Tomo Hashiguchi Morikuni Takigawa Toshiro Fujimoto |
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Affiliation: | (1) Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, 890 Kagoshima, Japan;(2) South Japan Health Science Center, 886 Miyazaki, Japan |
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Abstract: | 31P magnetic resonance spectroscopy was performed in 16 medicated schizophrenic patients with neuroleptic-resistant marked positive symptoms and in 16 healthy volunteers matched for age and sex in order to determine what changes in phosphorus metabolites are detected in such patients as compared to the controls. The schizophrenic patients showed an increased level of phosphodiesters in the bilateral medial temporal lobes. They also showed a decrease in the level of -ATP in the left medial temporal lobe. These findings suggest that schizophrenic patients with prominent positive symptoms refractory to neuroleptics may have a disturbance of bilateral membrane phospholipid and left-sided high-energy phosphate metabolism in the medial temporal lobe. |
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Keywords: | Phosphorus magnetic resonance spectroscopy Schizophrenia Medial temporal lobe Prominent positive symptoms |
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