| 肝癌细胞粘弹性的实验研究 |
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| 引用本文： | 张钢,龙勉,吴泽志. 肝癌细胞粘弹性的实验研究[J]. 解放军医学杂志, 2001, 26(3): 204-206 |
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| 作者姓名： | 张钢 龙勉 吴泽志 |
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| 作者单位： | 1. 第三军医大学病理生理学教研室
2. 重庆大学生物工程研究院 |
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| 基金项目： | 国家自然科学基金资助课题! (编号 3 93 70 198) |
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| 摘 要： | 作者用微管吸吮技术测定了肝癌细胞的粘弹性，并进一步研究了秋水仙素和细胞松驰素D对其影响。结果表明，肝癌细胞弹性系数较肝细胞高，秋水仙素作用后使肝癌细胞与肝细胞的粘弹性以不同的效应方式和强度发生变化，细胞松驰素D则使两种细胞粘弹性均呈现相似的下降趋势。上述结果反映了癌细胞在骨架结构和机能上的变化，这种变化可能对癌细胞浸润和转移有影响。
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| 关 键 词： | 抗肿瘤药 细胞粘附 肝癌细胞 秋水仙素 粘弹性 细胞培养 细胞松驰素D |
| 修稿时间： | 2000-10-15 |
EXPERIMENTAL STUDY ON VISCOELASTIC PROPERTIES OF HEPATOCELLULAR CARCINOMA CELLS |
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| Zhang Gang,LONG Mian,Wu Zezhi. EXPERIMENTAL STUDY ON VISCOELASTIC PROPERTIES OF HEPATOCELLULAR CARCINOMA CELLS[J]. Medical Journal of Chinese People's Liberation Army, 2001, 26(3): 204-206 |
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| Authors: | Zhang Gang LONG Mian Wu Zezhi |
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| Affiliation: | Zhang Gang,Long Mian,Wu Zezhi. The Department of Pathophysiology,Third Military Medical University,Chongqing,400038 |
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| Abstract: | The viscoelastic properties of hepatocellular carcinoma (HCC) cells were measured by means of micropipette aspiration technique. Further,the authors studied the changes in viscoelastic coefficients by treating with colchicine and cytochalasin D. The results showed that the elastic coefficients of HCC cells were obviously higher than the corresponding value of hepatocytes. By treating with colchicine, the effects on viscoelastic properties of HCC cells were obviously different in ways and extents from those on viscoelastic properties of hepatocytes.,but the viscoelastic properties of hepatocytes by treated with cytochalasin D had the same trend of decreasing as those of HCC cells. These results represent the change in cytoskeleton structure and function among hepatocytes and HCC cells, this change might affect tumor cells invasion and metastasis. |
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| Keywords: | turnor cells cultured antineoplastic agents cell adhesion |
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