复合药物治疗绝经后骨质疏松症

应用以雌激素、海螵蛸和维生素Ｄ等为主要成分的复合药物治疗绝经后骨质疏松症１７５例，６个月后随访１５８例，骨痛改善９２．５％，前臂及腰椎骨密度显著提高（Ｐ＜０．０５）；治疗１２个月后随访１２７例，骨痛改善达９６．４％，骨密度进一步提高（Ｐ＜０．０１）。用药初有９．１％的患者出现白带增多或乳房胀不适，几天后症状自行缓解；有３．５％的病人因子宫出血而停药。研究认为复合药物治疗绝经后骨质疏松症具有缓解疼痛，提高骨量，预防骨丢失，副反应轻微的特点。

Composite drug treatment of menopausal osteoporosis

175 menopausal osteoporotic patients were treated with composite medicine consisted of estrogen, cuttlebone, vitamin D, etc. After 6 months in the 158 cases that were followed up, bone pain was relieved in 92 2% of the patients and bone density was significantly increased in all the patients ( P <0 05). After 12 months in the 127 cases that were followed up,bone pain relief appeared in 96 4% and bone density was further increased ( P <0 01). As side effects, leukorrhagia and breast pain appearred in 9 1% of the patients at the beginning and later they disappeared. In about 3 5% of the cases, the treatment should be stopped,because they developed vaginal bleeding. It is thus concluded that the composite medicine relieves bone pain, increases bone density and prevents bone loss, but it may cause some side effects.