The effect of individual HLA-A and -B mismatches on the generation of cytotoxic T lymphocyte precursors |
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| Authors: | L Zhang S van Bree J J van Rood F H Claas |
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| Affiliation: | Department of Immunohaematology and Blood bank, University Hospital, Leiden, The Netherlands. |
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| Abstract: | In order to study the correlation between HLA mismatches and the cytotoxic T lymphocyte precursor frequency, we used a limiting dilution analysis to determine the CTLp frequencies against individual mismatched HLA-A and -B alloantigens in 21 patients waiting for a renal transplant. Altogether, thirty-three mismatched HLA-A antigens and 55 HLA-B antigens were tested. The CTLp frequencies against mismatches of HLA-B locus antigens were found to be significantly higher than those against HLA-A antigens (P less than 0.002). This may explain why matching for HLA-B antigens is more important for a good renal allograft survival than matching for HLA-A antigens. |
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