Iodine-125 Brachytherapy of Brain Stem Tumors |
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Authors: | Jenö Julow MD Árpád Viola Tibor Major István Valálik Sarolta Sági László Mangel Beáta R Kovács Imre Repa Gábor Bajzik Takácsi N Zoltán György Németh |
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Institution: | Department of Neurosurgery, St. John's Hospital, Budapest, Hungary. h12494jul@ella.hu |
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Abstract: | PURPOSE: To report on iodine-125 ((125)I) interstitial irradiation in the treatment of brain stem tumors. PATIENTS AND METHODS: Two patients with brain stem tumors were treated with CT- and image fusion-guided (125)I stereotactic brachytherapy. RESULTS: By March 2003, the patients had been followed up for 47 and 13 months, respectively. In case 1, the tumor volume was 1.98 cm(3) on the control CT, indicating a 65.5% shrinkage as compared to a target volume of 5.73 cm3 at the time of brachytherapy. In case 2, shrinkage was more distinct. After irradiation, the cyst volume was 0.16 cm(3) on the control MRI, indicating a 97.4% shrinkage as compared to a target volume of 6.05 cm(3) at the time of brachytherapy, i. e., the metastasis had virtually disappeared. CONCLUSION: CT- and image fusion-guided (125)I stereotactic brachytherapy can be performed during the biopsy session. The procedure can be well planned dosimetrically and is surgically precise. |
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