| 卵巢恶性肿瘤组织中HLA—G、HLA—E的表达及意义 |
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| 引用本文： | 王建英,许茜,吴淑娟,李勇,程建新. 卵巢恶性肿瘤组织中HLA—G、HLA—E的表达及意义[J]. 山东医药, 2010, 50(15): 1-3 |
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| 作者姓名： | 王建英 许茜 吴淑娟 李勇 程建新 |
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| 作者单位： | 河北医科大学第四医院,石家庄,050011 |
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| 基金项目： | 河北省科学技术研究与发展计划项目 |
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| 摘 要： | 目的探讨人白细胞抗原（HLA）在卵巢恶性肿瘤发生、发展中的作用。方法采用RT—PCR和流式细胞分析技术检测60份卵巢恶性肿瘤组织（恶性组）、30份卵巢良性肿瘤组织（良性组）和10份正常卵巢组织（对照组）标本中HLA-G、HLA—E的表达。结果恶性组HLA—G、HLA-E阳性表达率显著高于良性组与对照组（P均〈0．05）；HLA—G、HLA—E表达与肿瘤组织类型无关，与临床分期、病理分级显著相关，临床期别越晚、组织分化越差，抗原表达水平越高。结论HLA-G、HIA-E参与了卵巢恶性肿瘤的发生、发展过程，可能机制为癌细胞产生免疫耐受，逃逸宿主的免疫监视。
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| 关 键 词： | 卵巢肿瘤 人自细胞抗原-G 人白细胞抗原-E 免疫逃逸 |
Expression and significance of HLA-G and HLA-E in the tissue of ovarian malignant tumor |
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| WANG Jian-ying,XU Qian,WU Shu-juan,LI Yong,CHENG Jian-xin. Expression and significance of HLA-G and HLA-E in the tissue of ovarian malignant tumor[J]. Shandong Medical Journal, 2010, 50(15): 1-3 |
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| Authors: | WANG Jian-ying XU Qian WU Shu-juan LI Yong CHENG Jian-xin |
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| Affiliation: | WANG Jian-ying,XU Qian,WU Shu-juan,LI Yong,CHENG Jian-xin(The Forth Hospital of Hebei Medical University,Shijiazhuang 050011,P.R.China) |
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| Abstract: | Objective To investigate the significance of human leukocyte antigen(HLA) in the occurrence and development of ovarian malignant neoplasm.Methods RT-PCR and flow cytometry methods were performed to examine the expression of HLA-G and HLA-E in 60 tissues of ovarian malignant neoplasm(malignant group),30 tissues of benign ovarian(benign group)and 10 tissues of normal ovarian(control group).Results The positive rates of HLA-G and HLA-E in malignant group were higher than those in the benign group and control g... |
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| Keywords: | ovarian neoplasm human leukocyte antigen-G human leukocyte antigen-E immune escape |
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