| 促红细胞生成素对顺铂急性肾损伤的保护作用 |
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| 引用本文： | 曾建,白光辉.促红细胞生成素对顺铂急性肾损伤的保护作用[J].现代医药卫生,2009,25(4):483-484. |
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| 作者姓名： | 曾建 白光辉 |
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| 作者单位： | 曾建 (青海大学医学院,青海,西宁,810001)； 白光辉 (青海大学医学院附属医院肾内科,青海,西宁,810001)； |
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| 摘 要： | 目的：探讨促红细胞生成索（Erythopoietin，Epo）对顺铂（CDDP）急性肾损伤的保护作用及机制。方法：建立大鼠CDDP急性肾损伤动物模型，将SD大鼠随机分为生理盐水（NS）组、CDDP组及Epo治疗（CDDP＋Epo治疗），观察各组血清尿素氮（BUN）、血肌酐（Scr）和肾组织匀浆超氧化物歧化酶（SOD）、丙二醛（MDA）及肿瘤坏死因子-α（TNF—α）的变化。结果：Epo治疗组血清BUN、Scr及MDA、TNF-α较CDDP组显著下降（P〈0．05），SOD显著升高（P〈0．05）。结论：Epo可提高SOD，降低TNF—α对CDDP急性肾损伤具有保护作用。
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| 关 键 词： | 促红细胞生成素 顺铂 肾损伤 |
Protective effects of erythopoietin on cisplatin-induced aucte renal injury |
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| Institution: | ZENG Jian,BAI Guang-hui (1.Medical College, Qinghai Univercity,Xining, Qinghai 810001, China;2.Department of Nephrology,Affiliated Hospital of Medical College, Qinghai Univercity ,Xining, Qinghai 810001, China) |
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| Abstract: | Objective：To investigate the protective effect and mechanism of erythopoietin on cisplatin-induced auete renal injury in rats. Methods：The eisplatin-indueed auete renal injury rat model was induced and SD rats were randomly divided into NS group,CDDP- group and CDDP＋Epo group,then the levels of serum Scr,BUN and tissue SOD,MDA,TNF-α were determined in rats.Results：The levels of BUN, Scr and tissue MDA ,TNF-α were significandy lower in CDDP＋Epo group than those in CDDP group（P〈0.05） ,but the level of tissue SOD was higher in CDDP＋Epo group than that in CDDP group（P〈0.05）.Conclusion：Epo has protective effeets on eisplatin-indueed actue renal injury according to increasing SOD and decreasing TNF-α. |
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| Keywords: | Erythopoietin Cisplatin Renal injury |
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