生脉注射液对阻塞性黄疸术后内毒素内皮素及细胞因子的作用

目的：观察生脉注射液对阻塞性黄疸术后内毒素（LPS）、肿瘤坏死因子（TNF—α）、自细胞介素-6，8（IL-6，IL-8）及内皮素（ET）的作用。方法：将阻塞性黄疽患者及非黄疸的肝胆外科患者分成3组，术后给予一般治疗阻塞性黄疽组（0J）、非黄疸组（Non—OJ）及生脉注射液防治阻塞性黄疽组（观察组），动态观察血浆LPS、TNF-α、IL-6，IL-8及ET的变化。结果：观察组术后7天与术后1天相比．LPS、IL-6、IL-8、ET、TNF—α明显下降，低于或接近术前水平，其中黄疸对照组在术后7天与术后1天相比差异无显著性。结论：生脉注射液对阻塞性黄疸患者术后12S有拮抗作用，同时降低其他炎症介质水平，从而保护多器官功能。

Clinical study on the effect of shengmai injection on inflammatory mediator in post-operative patients with obstructive jaundice

Objective：To investigate the effect of shengmai injection on inflammatory mediator in obstructive jaundice. Methods： The patients with obstructive jaundice were randomly divided into 2 groups, 15 cases of non-jaundiced patients as another control group according to preoperative arrangement. The plasma ET, LPS,TNF-α,IL-6. IL-8 were measured pre-and post-operative 1,4,7 days. Results：LPS,TNF-α, IL-6. IL-8, ET level of shengmai injection group during post-operative 7 days obviously lowered as compared with the same group during post-operative 1 day.Conclusion：Post-operative using of shengmai injection might effectively decrease the perioperative level of plasma LIPS and other inflammatory mediator in the patients with obstructive jaundice. At the same time, shengmai injection may improve multiorgan injury by inhibiting inflammatory mediator.