Aluminium dust-induced lung disease in the pyro-powder-producing industry: detection by high-resolution computed tomography |
| |
Authors: | T Kraus K H Schaller J Angerer S Letzel |
| |
Institution: | (1) Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine of the University of Erlangen-Nuremberg, Schillerstrasse 25 and 29, D-91054 Erlangen, Germany e-mail: thomas.p.kraus@rzmail.uni-erlangen.de Tel.: +49-9131-8526133; Fax: +49-9131-8522317, DE |
| |
Abstract: | Objective: The aim of this case study was to investigate the suitability of high-resolution computed tomography (HRCT) for detecting
early stages of lung fibrosis induced by aluminium (Al) dust. Methods: A 40-year-old worker was studied who had worked as a stamper for 14 years in a plant producing aluminium powder and had been
exposed to high levels of aluminium dust during this time. The investigation included the collection of general data on health
and details on occupational history, immunological tests, a physical examination, lung function analysis, biological monitoring
of Al in plasma and urine, chest X-rays and HRCT. Results: For many years the man has suffered from an exercise-induced shortness of breath. Lung function analysis revealed a reduction
of the vital capacity to 57.5% of the predicted value. The Al concentration in plasma was 41.0 μg/l (upper reference value
10 μg/l) and in urine 407.4 μg/l upper reference value 15 μg/l, biological tolerance (BAT) value 200 μg/l] at the time of
diagnosis. Chest X-ray showed unspecific changes. HRCT findings were characterised by small, centrilobular, nodular opacities
and slightly thickened interlobular septae. Exposure to other fibrotic agents could be excluded. Conclusions: HRCT was more sensitive than chest X-rays for detecting this early stage of Al-dust-induced lung disease. The suitability
of HRCT in the surveillance of workers highly exposed to aluminium powder should be evaluated in further studies. Biological
monitoring can be used to define workers at high risk.
Received: 29 March 1999 / Accepted: 26 August 1999 |
| |
Keywords: | Computed tomography High-resolution CT Biological monitoring Aluminium Screening |
本文献已被 PubMed SpringerLink 等数据库收录! |
|