| 3′或4′甲基取代的黄酮类化合物的合成 |
| |
| 引用本文： | 杨家梅. 3′或4′甲基取代的黄酮类化合物的合成[J]. 药学学报, 1980, 15(11): 684-687 |
| |
| 作者姓名： | 杨家梅 |
| |
| 作者单位： | 上海医药工业研究院 |
| |
| 摘 要： | 在寻找计划生育新药的工作中,作者注意到白花丹(Plumbage zeylanica Linn.)在国内外药理过筛中,虽具有一定的抗早孕生理活性,但由于毒性大,有效剂量和致死量接近,不易求得满意的效果,难以推上临床应用。鉴于黄酮类化合物广泛地存在于植物中,早年已
|
| 收稿时间： | 1979-09-07 |
SYNTHESES OF SOME FLAVONOID COMPOUNDS WITH 3''- OR 4''- SUBSTITUTED METHYL GROUP |
| |
| Yang Jiamei. SYNTHESES OF SOME FLAVONOID COMPOUNDS WITH 3''- OR 4''- SUBSTITUTED METHYL GROUP[J]. Acta pharmaceutica Sinica, 1980, 15(11): 684-687 |
| |
| Authors: | Yang Jiamei |
| |
| Abstract: | The syntheses and screening for five series of new flavonoid compounds with 3'-or 4'-substituted methyl gronp are reported. Among these compounds, the anti-early-pregnancy activity of I4 in mice has been noticed to be comparable with that of the active principle of Plumbago zeylanica, 2-methyl-5-hydroxy-1,4-naphthoquinone. Compounds Ⅳ and V3 resemble in strncture apigenin, and recordil (a remedy for coronary insufficiency) respectively. Their structure-activity relationships are under investigation. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
|
