复方蒲芩胶囊联合阿奇霉素治疗肺炎的临床研究

目的研究复方蒲芩胶囊联合阿奇霉素胶囊治疗肺炎的临床疗效。方法选取2015年4月—2017年4月天门市第一人民医院收治的肺炎患者120例作为研究对象,所有患者随机分为对照组和治疗组,每组各60例。对照组口服阿奇霉素胶囊,1粒/次,1次/d。治疗组在对照组基础上口服复方蒲芩胶囊,3粒/次,3次/d。两组患者均连续治疗10 d。观察两组的临床疗效,比较两组的临床症状消失时间和血清炎性因子水平。结果治疗后,对照组和治疗组的总有效率分别为78.33%、93.33%,两组比较差异有统计学意义(P0.05)。治疗后,治疗组咳嗽消失时间、白细胞恢复正常时间、体温恢复正常时间和啰音消失时间均短于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组超敏C-反应蛋白(hs-CRP)、白细胞计数、中性粒细胞数水平显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组血清炎性因子水平明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论复方蒲芩胶囊联合阿奇霉素胶囊治疗肺炎具有较好的临床疗效,可改善临床症状,调节炎性因子水平,安全性较好,具有一定的临床推广应用价值。

Clinical study on Compound Puqin Capsules combined with azithromycin in treatment of pneumonia

Objective To study the clinical efficacy of Compound Puqin Capsules combined with Azithromycin Capsules in treatment of pneumonia. Methods Patients (120 cases) with pneumonia in Tianmen First People''s Hospital from April 2015 to April 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Azithromycin Capsules, 1 grain/time, once daily. Patients in the treatment group were po administered with Compound Puqin Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the clinical symptoms disappeared time and the level of serum inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.33% and 93.33%, respectively, and there was difference between two groups (P < 0.05). After treatment, the cough disappeared time, the white blood cell count returned to normal time, the body temperature returned to normal time, and the rale disappear time in the treatment group were shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, the levels of hs-CRP, white blood cell count, and neutrophil count in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the levels of serum inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Compound Puqin Capsules combined with Azithromycin Capsules has clinical curative effect in treatment of pneumonia, can improve clinical symptoms, and regulate the level of inflammatory factors, with good safety, which has a certain clinical application value.