小儿肺热咳喘口服液联合美洛西林钠治疗小儿肺炎的临床研究

目的观察小儿肺热咳喘口服液联合美洛西林钠治疗小儿肺炎的临床疗效。方法选取2016年7月—2017年6月天津市西青医院收治的106例小儿肺炎患儿,随机分为对照组和治疗组,每组各53例。对照组静脉滴注注射用美洛西林钠,0.1 g/(kg·d),3次/d;治疗组在对照组治疗基础上口服小儿肺热咳喘口服液,10 mL/次,4次/d。两组均连续治疗10 d。观察两组的临床疗效,比较两组临床症状体征改善情况。比较两组治疗前后C反应蛋白(CRP)、白细胞介素-6(IL-6)水平的变化情况。结果治疗后,对照组和治疗组的总有效率分别为83.02%、94.34%,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组咳嗽消失时间、喘息消失时间、肺部啰音消失时间、退热时间均显著短于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组CRP、IL-6水平均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组CRP、IL-6水平显著低于对照组,两组比较差异具有统计学意义(P0.05)。结论小儿肺热咳喘口服液联合美洛西林钠治疗小儿肺炎具有较好的临床疗效,可迅速改善患者临床症状体征,降低CRP、IL-6因子水平,具有一定的临床推广应用价值。

Clinical study on Xiaoer Feire Kechuan Oral Liquid combined with mezlocillin sodium in treatment of infantile pneumonia

Objective To observe the clinical curative effect of Xiaoer Feire Kechuan Oral Liquid combined with mezlocillin sodium in treatment of infantile pneumonia. Methods Children (106 cases) with infantile pneumonia in Tianjin Xiqing Hospital from July 2016 to June 2017 were randomly divided into control (53 cases) and treatment (53 cases) group. Patients in the control group were iv administered with Mezlocillin Sodium for injection, 0.1 g/(kg·d), three times daily. Patients in the treatment group were po administered with Xiaoer Feire Kechuan Oral Liquid, 10 mL/time, four times daily. Patients in two groups were treated for 10 d. After treatment, the clincial efficacies were evaluated, and the improvement of clinical symptoms and signs were compared between the two groups. After treatment, the changes of CRP and IL-6 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group were 83.02% and 94.34%, and there were differences between two groups (P<0.05). After treatment, cough disappeared time, wheezing disappeared time, lung murmur disappeared time, and heat degenerative time in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P<0.05). After treatment, CRP and IL-6 in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, CRP and IL-6 in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). Conclusion Xiaoer Feire Kechuan Oral Liquid combined with mezlocillin sodium has significant clinical effect in treatment of infantile pneumonia, and clinical symptoms and signs of patients can be improved rapidly, and can reduce the levels of CRP and IL-6, which has a certain clinical application value.