头孢地嗪致不良反应的文献分析

目的探讨头孢地嗪致不良反应发生的规律和特点,为临床合理用药提供参考。方法检索从建库至2018年2月Pubmed、中国学术期刊(网络版)、万方数字化期刊全文库、中文科技期刊全文数据库(维普)中关于头孢地嗪不良反应的个案报道,并进行统计和分析。结果共检索到24篇文献,33例病例。年龄集中在0~18岁和60岁以上。给药方式主要为静脉滴注。原患疾病主要以呼吸系统感染为主。不良反应大多发生于用药30 min内,构成比为42.42%。头孢地嗪引发的不良反应主要涉及全身性损害、消化系统损害、皮肤及附件损害、呼吸系统损害、心血管系统损害和中枢神经系统损害,全身性损害例数最多,临床表现主要为过敏性样反应和过敏性休克。结论临床应重视头孢地嗪不良反应的危害性,加强药学监护,尽量避免或减少其所致不良反应的发生,确保患者用药安全。

Literature analysis of adverse reactions induced by cefodizime

Objective To investigate the regularities and characteristics of adverse reactions caused by cefodizime, and to provide a reference for clinical rational drug use. Methods PubMed databases, Chinese Academic Journal (online), Wangfang Database, Chinese Science, and Technology Journal Full-text Database (VIP) were retrieved from building database to February 2018, and the documents of ADR induced by cefodizime were analyzed and discussed. Results A total of 24 literatures with 33 patients were retrieved. The ages of patients were mainly 0-18 years old and above 60 years old. The main method of administration was intravenous drip. The primary disease was mainly respiratory infection. The most cases occured in the medication in 30 min, accounting for 42.42%. ADR induced by cefodizime mainly occured in systemic damage, digestive system hurt, skin and accessory damage, cardiovascular system damage, and nervous system damage, in which systemic damage took the most ratios. And the main clinical manifestation were anaphylaxis and allergic shock. Conclusion Importance should be attached to the danger of ADR induced by cefodizime and pharmaceutical care should be strengthened, to avoid or reduce the incidence of ADR to ensure medication safety.