连花清瘟颗粒联合哌拉西林舒巴坦治疗肺炎的临床观察

目的研究连花清瘟颗粒联合注射用哌拉西林钠舒巴坦钠治疗肺炎的临床疗效。方法选取2016年11月—2018年4月绵阳万江眼科医院接收的肺炎患者120例为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组静脉滴注注射用哌拉西林钠舒巴坦钠,5 g加入到0.9%氯化钠注射液100 m L中,1 h内滴完,1次/8 h。治疗组在对照组治疗的基础上口服连花清瘟颗粒,1袋/次,3次/d。两组患者均持续治疗14 d。观察两组的临床疗效,比较两组的临床症状消失时间和血清炎症因子水平。结果治疗后,对照组和治疗组的总有效率分别为80.00%、95.00%,两组比较差异有统计学意义(P0.05)。治疗后,治疗组白细胞恢复正常时间、体温恢复正常时间、咳嗽消失时间和啰音消失时间均短于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组白细胞(WBC)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平均显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组血清炎症因子水平明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论连花清瘟颗粒联合注射用哌拉西林钠舒巴坦钠治疗肺炎具有较好的临床疗效,能改善患者临床症状,调节患者炎性因子水平,安全性较好,具有一定的临床推广应用价值。

Clinical observation of Lianhua Qingwen Capsules combined with piperacillin and sulbactam in treatment of pneumonia

Objective To study the clinical efficacy of Lianhua Qingwen Capsules combined with Piperacillin Sodium and Sulbactam Sodium for injection in treatment of pneumonia. Methods Patients (120 cases) with pneumonia in Mianyang Wanjiang Ophthalmologic Hospital from November 2016 to April 2018 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were iv administered with Piperacillin Sodium and Sulbactam Sodium for injection, 5 g added into normal saline 100 mL, dripped completion in 1 h, 1 time every 8 h. Patients in the treatment group were po administered with Lianhua Qingwen Capsules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the disappearance time of clinical symptoms and the levels of serum inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.00%, respectively, and there was difference between two groups (P < 0.05). After treatment, the recovery time of white blood cell and body temperature, coughing disappearance time, and rale disappearance time in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, the levels of WBC, hs-CRP, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the levels of serum inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Lianhua Qingwen Capsules combined with Piperacillin Sodium and Sulbactam Sodium for injection has clinical curative effect in treatment of pneumonia, can improve clinical symptoms, regulate the levels of serum inflammatory factors, with good safety, which has a certain clinical application value.