强骨胶囊联合骨瓜提取物注射液治疗骨质疏松性股骨骨折的临床研究

目的探讨强骨胶囊联合骨瓜提取物注射液治疗骨质疏松性股骨骨折的临床效果。方法选取2015年6月—2017年6月上海市浦东新区光明中医院收治的98例骨质疏松性股骨骨折患者,随机分为对照组和治疗组,每组各49例。对照组静脉滴注骨瓜提取物注射液,100 mg加入250 m L生理盐水均匀混合,1次/d,连续治疗20 d为1个疗程,停药10 d;再按以上方案连用3个疗程。治疗组在对照组治疗基础上口服强骨胶囊,1粒/次,3次/d。两组均连续治疗3个月。观察两组的临床疗效,比较两组治疗1、3个月时骨痂骨密度(BMD)水平和骨愈合时间。比较两组治疗前后VAS评分、股骨颈BMD、HHS评分、钙(Ca)、磷(P)、碱性磷酸酶(ALP)、骨钙素(BGP)、24 h尿标本中羟脯氨酸(HOP)水平的变化情况。结果治疗后,对照组和治疗组的总有效率分别为79.59%、93.88%,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组治疗1、3个月时骨痂BMD值显著高于对照组治疗同期,治疗组骨折愈合时间显著短于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组VAS评分、Ca、ALP水平和24 h尿HOP显著降低,股骨颈BMD、HHS评分、P、BGP显著升高,同组治疗前后比较差异有统计学意义(P0.05);治疗后,治疗组VAS评分、Ca、ALP水平和24 h尿HOP低于对照组,股骨颈BMD、HHS评分、P、BGP显著高于对照组,两组比较差异具有统计学意义(P0.05)。结论强骨胶囊联合骨瓜提取物注射液治疗骨质疏松性股骨骨折具有较好的临床疗效,可有效减轻患者疼痛,增加骨密度,促进骨折愈合,调控骨代谢平衡,具有一定的临床推广应用价值。

Clinical study on Qianggu Capsules combined with Gugua Extract Injection in treatment of osteoporotic femoral fracture

Objective To investigate the clinical effect of Qianggu Capsules combined with Gugua Extract Injection in treatment of osteoporotic femoral fracture. Methods Patients (98 cases) with osteoporotic femoral fracture in Guangming Chinese Medicine Hospital of Pudong New Area Shanghai from June 2015 to June 2017 were randomly divided into control (49 cases) and treatment (49 cases) groups. Patients in the control group were iv administered with Gugua Extract Injection, 100 mg added into 250 mL normal saline, once daily, 20 d for one course of treatment, discontinuation of 10 d. Follow the above scheme for three courses. Patients in the treatment group were po administered with Qianggu Capsules on the basis of the control group. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the osteotylus BMD in 1 and 3 months of the treatment and bone healing time in two groups were compared. The changes of VAS score, femoral neck BMD, HHS score, Ca, P, ALP, BGP, and 24 h HOP in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 79.59% and 93.88%, and there were differences between two groups (P < 0.05). After treatment, the osteotylus BMD in 1 and 3 months of the treatment in the treatment group were higher than those in the control group, and bone healing time in the treatment group was shorter than that in the control group, and there were differences between two groups (P < 0.05). After treatment, VAS score, Ca, ALP, and 24 h HOP in two groups were significantly decreased, but femoral neck BMD, HHS score, P, and BGP were significantly increased, and there were differences in the same group (P < 0.05). After treatment, VAS score, Ca, ALP, and 24 h HOP in the treatment group were lower than those in the control group, but femoral neck BMD, HHS score, P, and BGP were higher than those in the control group, there were differences between two groups (P < 0.05). Conclusion Qianggu Capsules combined with Gugua Extract Injection has significant clinical effect in treatment of osteoporotic femoral fracture, and can relieve pain effectively, increase bone mineral density, also can promote fracture healing and regulate bone metabolism balance, which has a certain clinical application value.