苦碟子注射液联合纳洛酮治疗后循环缺血性眩晕的临床研究

目的探讨苦碟子注射液联合纳洛酮治疗后循环缺血性眩晕的临床效果。方法选择浚县人民医院2014年6月—2016年12月收治的94例后循环缺血性眩晕患者,随机分成对照组和治疗组,每组各47例。对照组静脉滴注盐酸纳洛酮注射液,2.4 mg/次,1次/d。治疗组在对照组的基础上静脉滴注苦碟子注射液,20 mL加入生理盐水250 mL,1次/d。两组患者均持续治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者内皮功能、血流动力学、眩晕症状量表评分以及不良反应情况。结果治疗后,对照组和治疗组的临床总有效率分别为78.22%、95.74%,两组比较差异具有统计学意义(P0.05)。两组内皮素-1(ET-1)、血管性血友病因子(vWF)、血栓调节蛋白(TM)均较治疗前显著降低,降钙素基因相关肽(CGRP)均较治疗前升高,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组内皮功能明显优于对照组,两组比较差异具有统计学意义(P0.05)。两组椎基底动脉、右侧椎动脉和左侧椎动脉指标均较治疗前显著降低,同组比较差异具有统计学意义(P0.05);且治疗组这些血流动力学指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。两组眩晕症状量表评分均较治疗前显著降低,同组比较差异具有统计学意义(P0.05);且治疗组眩晕症状量表评分明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论苦碟子注射液联合纳洛酮治疗后循环缺血性眩晕的疗效显著,能够有效纠正内皮功能及血流动力学,促进疾病的恢复,具有一定的临床推广应用价值。

Clinical study on Kudiezi Injection combined with naloxone in treatment of posterior circulation ischemic dizziness

Objective To discuss the clinical effect of Kudiezi Injection combined with naloxone in treatment of posterior circulation ischemic dizziness. Methods Patients (94 cases) with posterior circulation ischemic dizziness in Junxian People''s Hospital from June 2014 to December 2016 were randomly divided into controland treatment groups. Each group had 47 cases. Patients in the control group were iv administered with Naloxone Hydrochloride Injection, 2.4 mg/time, once daily. Patients in the treatment group were iv administered with Kudiezi Injection on the basis of the control group, 20 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and endothelial function, hemodynamics, vertigo symptom scale score, and adverse reactions in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control and treatment groups were 78.22% and 95.74%, respectively, and there were differences between two groups (P < 0.05). ET-1, vWF, and TM in two groups were significantly decreased, but CGRP was significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these endothelial function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Vertebrobasilar artery, right vertebral artery, and left vertebral artery indexes in two groups were significantly decreased, and there were differences between two groups (P < 0.05). And those hemodynamic indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). The vertigo symptom scale score in two groups was decreased (P < 0.05), and the score in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Kudiezi Injection combined with naloxone has good effect in treatment of posterior circulation ischemic dizziness, and can effectively correct endothelial function and hemodynamics, and promote the recovery of disease, which has a certain clinical application value.