麒麟丸联合氯米芬治疗多囊卵巢综合征的临床研究

目的探讨麒麟丸联合枸橼酸氯米芬片治疗多囊卵巢综合征的临床疗效。方法选取2016年8月—2017年7月上海市嘉定区妇幼保健院治疗的104例多囊卵巢综合征患者为研究对象,随机将患者分为对照组和治疗组,每组各52例。对照组口服枸橼酸氯米芬片,在每个月经第5天服用,50 mg/次,1次/d,连续治疗5 d。治疗组在对照组治疗的基础上口服麒麟丸,6g/次,3次/d。两组患者均治疗3个月。观察两组患者临床疗效,比较治疗前后两组的临床症状、性激素水平、排卵情况和胰岛素抵抗指标。结果治疗后,对照组和治疗组的总有效率分别为78.8%、94.2%,两组比较差异有统计学意义(P0.05)。治疗后,两组体质量指数(BMI)、多毛评分、卵巢体积显著降低,子宫内膜厚度均显著升高,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组这些指标显著优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组黄体生成素(LH)、睾酮(T)水平均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);治疗组LH、T显著低于对照组,两组比较差异具有统计学意义(P0.05)。治疗组排卵率、成熟卵泡数、妊娠率均显著高于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组空腹血糖(FPG)、空腹胰岛素(FINS)、稳态模型评估的胰岛素抵抗指数(HOMA-IR)显著降低,胰岛素作用指数(IAI)均显著升高,同组治疗前后比较差异具有统计学意义(P0.05)。治疗后,治疗组这些指标显著优于对照组,两组比较差异具有统计学意义(P0.05)。结论麒麟丸联合枸橼酸氯米芬片治疗多囊卵巢综合征具有较好的临床疗效,可显著改善患者的临床症状,调节性激素和胰岛素抵抗紊乱情况,促进患者排卵和妊娠,具有一定的临床推广价值。

Clinical study on Qilin Pills combined with clomiphene in treatment of polycystic ovary syndrome

Objective To investigate the clinical efficacy of Qilin Pills combined with Clomiphene Citrate Tablets in treatment of polycystic ovary syndrome. Methods Women (104 cases) with polycystic ovary syndrome in Shanghai Jiading District Maternal and Child Health Care Hospital from August 2016 to July 2017 were randomly divided into control and treatment groups, and each group had 52 cases. Women in the control group were po administered with Clomiphene Citrate Tablets on the fifth day of every menstruation for 5 d continuously, 50 mg/time, once daily. Women in the treatment group were po administered with Qilin Pills on the basis of the control group, 6 g/time, three times daily. Women in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and the clinical symptoms, sex hormone levels, ovulation, and insulin resistance indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment group were 78.8% and 94.2%, and there were differences between two groups (P<0.05). After treatment, BMI, mFG score, and ovarian volume in two groups were significantly decreased, but endometrial thickness in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the observation indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, LH and T in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, LH and T in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the ovulation rates, the numbers of mature follicles, and the rates of pregnancy in the treatment group were significantly higher than those in the control group, and there were differences between two groups (P<0.05). After treatment, FPG, FINS, and HOMA-IR in two groups were significantly decreased, but IAI in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the observation indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Qilin Pills combined with Clomiphene Citrate Tablets has clinical curative effect in treatment of polycystic ovary syndrome, can significantly improve clinical symptoms, regulate sex hormone and insulin resistance, and promote ovulation and pregnancy, which has a certain clinical application value.