调经促孕丸联合氯米芬治疗肥胖型多囊卵巢综合征不孕的疗效观察

目的探究调经促孕丸联合枸橼酸氯米芬胶囊治疗肥胖型多囊卵巢综合征不孕的临床疗效。方法选取2014年6月—2017年3月到商南县中医医院接受治疗的肥胖型多囊卵巢综合症患者102例为研究对象,按随机数表法分为对照组和治疗组,每组各51例。对照组从月经周期第5天开始口服枸橼酸氯米芬胶囊,50 mg/次,1次/d。治疗组在对照组的基础上从月经周期第5天开始口服调经促孕丸,5 g/次,2次/d。1个月为1个疗程,两组患者均连续治疗3个疗程。观察和比较两组的排卵率、妊娠率、妊娠早期流产率、激素水平和子宫内膜厚度。结果治疗后,对照组和治疗组排卵率分别为71%、92%,妊娠率分别为69%、91%,妊娠早期流产率分别为10%、2%,两组排卵率、妊娠率、妊娠早期流产率比较差异具有统计学意义(P0.05)。治疗后,两组卵泡刺激素(FSH)、黄体生成激素(LH)、LH/FSH水平均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组这些激素水平明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组子宫内膜厚度均显著减少,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组子宫内膜厚度明显小于对照组,两组比较差异具有统计学意义(P0.05)。结论调经促孕丸联合枸橼酸氯米芬胶囊治疗肥胖型多囊卵巢综合征不孕具有较好的临床疗效,能降低FSH、LH水平,改善子宫内膜厚度,提高排卵率和妊娠率,降低妊娠早期流产率,具有一定的临床推广应用价值。

Clinical observation of Tiaojing Cuyun Pills combined with clomifene in treatment of obesity polycystic ovarian syndrome infertility

Objective To investigate the clinical effect of Tiaojing Cuyun Pills combined with Clomifene Citrate Capsules in treatment of obesity polycystic ovarian syndrome infertility. Methods Patients (102 cases) with obesity polycystic ovarian syndrome infertility in Shangnan County Chinese Medicine Hospital from June 2014 to March 2017 were randomly divided into control and treatment groups, and each group had 51 cases. Patients in the control group were po administered with Clomifene Citrate Capsules from the fifth day of menstrual cycle, 50 mg/time, once daily. Patients in the treatment group were po administered with Tiaojing Cuyun Pills on the basis of the control group, 5 g/time, twice daily. One month was 1 course, and patients in two groups were treated for 3 courses. After treatment, the ovulation rate, pregnancy rate, early pregnancy abortion rate, hormone level, and endometrial thickness in two groups were compared. Results After treatment, the ovulation rate in the control and treatment groups were 71% and 92%, respectively; the oviposit rates in the control and treatment groups were 69% and 91%, respectively, and the early pregnancy abortion rates in the control and treatment groups were 10% and 2%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of FSH, LH, and LH/FSH in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the hormone levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the endometrial thicknesses in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the endometrial thickness >in the treatment group was significantly thicker than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Tiaojing Cuyun Pills combined with Clomifene Citrate Capsules has clinical curative effect in treatment of obesity polycystic ovarian syndrome infertility, can decrease the levels of FSH and LH, improve the endometrial thickness, increase the ovulation rate and pregnancy rate, reduce the early pregnancy abortion rate, which has a certain clinical application value.