宫炎康颗粒联合甲硝唑治疗慢性盆腔炎的临床研究

目的探讨宫炎康颗粒联合甲硝唑氯化钠注射液治疗慢性盆腔炎的临床疗效。方法选取2016年5月—2017年1月于天津市第一医院进行治疗的盆腔炎患者92例为研究对象,采用随机数表法将所有患者分为对照组和治疗组,每组各46例。对照组静脉滴注甲硝唑氯化钠注射液,0.5 g/次,2次/d。治疗组在对照组基础上口服宫炎康颗粒,18 g/次,2次/d。两组患者均持续治疗2周。观察两组的临床疗效,比较两组的临床症状评分和血清指标。结果治疗后,对照组和治疗组的总有效率分别为80.4%、93.5%,两组比较差异有统计学意义(P0.05)。治疗后,两组小腹疼痛、下腹坠胀、白带量、腰骶胀痛评分和总分明显降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些临床症状评分明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组血清降钙素原(PCT)、C-反应蛋白(CRP)、红细胞沉降率(ESR)水平显著降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组这些血清指标水平明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论宫炎康颗粒联合甲硝唑氯化钠注射液治疗慢性盆腔炎具有较好的疗效,能改善临床症状,降低血清PCT、CRP、ESR水平,具有一定的临床推广应用价值。

Clinical study on Gongyankang Granules combined with metronidazole in treatment of chronic pelvic inflammatory disease

Objective To investigate clinical curative effect of Gongyankang Granules combined with Metronidazole and Sodium Chloride Injection in treatment of chronic pelvic inflammatory disease. Methods Patients (92 cases) with chronic pelvic inflammatory disease in Tianjin First Hospital from May 2016 to January 2017 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were iv administered with Metronidazole and Sodium Chloride Injection, 0.5 g/time, twice daily. Patients in the treatment group were po administered with Gongyankang Granules on the basis of the control group, 18 g/time, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom scores and serum indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.4% and 93.5%, respectively, and there was difference between two groups (P<0.05). After treatment, the scores of lower abdominal pain, lower abdominal distention, leucorrhea amount, and lumbosacral distending pain, and total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the clinical symptom scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of PCT, CRP, and ESR in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Gongyankang Granules combined with Metronidazole and Sodium Chloride Injection has clinical curative effect in treatment of chronic pelvic inflammatory disease, can improve clinical symptoms, decrease the levels of PCT, CRP, and ESR, which has a certain clinical application value.