佳蓉片联合曲普瑞林治疗子宫内膜异位症的临床研究

目的探讨佳蓉片联合注射用醋酸曲普瑞林治疗子宫内膜异位症的临床疗效。方法选取2016年9月—2017年10月峨眉山市中医医院收治的子宫内膜异位症患者94例为研究对象,按照随机数字表法分为对照组和治疗组,每组各47例。对照组于月经来潮第1天肌肉注射注射用醋酸曲普瑞林,3.75 mg/次,1次/4周。治疗组在对照组治疗的基础上口服佳蓉片,4片/次,3次/d。两组均连续治疗12周。观察两组的临床疗效,比较两组的性激素、窦卵泡计数(AFC)、更年期综合征评定量表(Kupperman)评分和视觉模拟评分法(VAS)评分。结果治疗后,对照组和治疗组的总有效率分别为78.72%、93.62%,两组比较差异有统计学意义(P0.05)。治疗后,两组促卵泡成熟素(FSH)、促黄体生成素(LH)、雌二醇(E_2)、AFC显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组性激素和AFC明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组Kupperman评分、VAS评分明显降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论佳蓉片联合注射用醋酸曲普瑞林治疗子宫内膜异位症具有较好的临床疗效,可改善临床症状,调节性激素水平,具有一定的临床推广应用价值。

Clinical study on Jiarong Tablets combined with triptorelin in treatment of endometriosis

Objective To investigate the clinical efficacy of Jiarong Tablets combined with Triptorelin Acetate for injection in treatment of endometriosis. Methods Patients (94 cases) with endometriosis in Mount Emei Hospital of Traditional Chinese Medicine from September 2016 to October 2017 were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were im administered with Triptorelin Acetate for injection at the first day of menstruation, 3.75 mg/time, once every 4 weeks. Patients in the treatment group were po administered with Jiarong Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and sex hormone, AFC, Kupperman scores, and VAS scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.72% and 93.62%, respectively, and there was difference between two groups (P<0.05). After treatment, FSH, LH, E₂, and AFC in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, Kupperman scores and VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Jiarong Tablets combined with Triptorelin Acetate for injection has clinical curative effect in treatment of endometriosis, can improve clinical symptoms, and regulate sex hormone level, which has a certain clinical application value.