| 亲水性胆汁酸防治胆固醇结石作用机制的研究进展 |
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| 引用本文： | 王波,胡海.亲水性胆汁酸防治胆固醇结石作用机制的研究进展[J].现代药物与临床,2018,33(7):1854-1858. |
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| 作者姓名： | 王波 胡海 |
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| 作者单位： | 上海市东方医院(同济大学附属上海市东方医院)胆石科;同济大学医学院 |
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| 摘 要： | 胆汁酸主要在肝脏中合成,是胆汁的主要成分之一,其含量和成分的改变与胆固醇结石形成具有密切关系。亲水性胆汁酸在胆固醇结石的形成、治疗中起重要作用,其具有溶解胆汁中胆固醇并调节胆固醇饱和度的重要作用,减少成核异常及保护并改善胆囊收缩功能的作用。对亲水性胆汁酸对防治胆固醇结石形成的作用机制进行综述。
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| 关 键 词： | 胆固醇结石 胆汁酸 熊去氧胆酸 |
| 收稿时间： | 2018/4/25 0:00:00 |
Research progress on action mechanism of hydrophilic bile acids in prevention and treatment of cholesterol gallstone |
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| WANG Bo and HU Hai.Research progress on action mechanism of hydrophilic bile acids in prevention and treatment of cholesterol gallstone[J].Drugs & Clinic,2018,33(7):1854-1858. |
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| Authors: | WANG Bo and HU Hai |
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| Institution: | Department of Hepatobiliary Surgery, Shanghai Oriental Hospital(Oriental Hospital Affiliated of Tongji University), Shanghai 200120, China;School of Medicine, Tongji University, Shanghai 200333, China and Department of Hepatobiliary Surgery, Shanghai Oriental Hospital(Oriental Hospital Affiliated of Tongji University), Shanghai 200120, China |
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| Abstract: | Bile acids are synthesized from cholesterol in the liver. It''s one of the main components of bile, and the change of its content and composition is closely related to the formation of cholesterol gallstones. Hydrophilic bile acids play an important role in cholesterol gallstones'' formation and treatment, which have an important role in dissolving cholesterol and regulating the saturation of cholesterol, reducing the abnormal nucleation, protecting and improving the contraction function of the gallbladder. In this paper, the action mechanism of hydrophilic bile acids in prevention and treatment of cholesterol gallstone are reviewed. |
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| Keywords: | cholesterol gallstone bile acids ursodeoxycholic acid |
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